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Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection

机译：跨多个亚型的gp41中保守的阳性选择信号以及在急性和慢性HIV-1亚型C感染期间采样的gp41序列中可检测到的选择信号差异

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摘要

BackgroundThe high diversity of HIV variants driving the global AIDS epidemic has caused many to doubt whether an effective vaccine against the virus is possible. However, by identifying the selective forces that are driving the ongoing diversification of HIV and characterising their genetic consequences, it may be possible to design vaccines that pre-empt some of the virus' more common evasion tactics. One component of such vaccines might be the envelope protein, gp41. Besides being targeted by both the humoral and cellular arms of the immune system this protein mediates fusion between viral and target cell membranes and is likely to be a primary determinant of HIV transmissibility.

机译：背景技术导致全球艾滋病流行的HIV变异体的高度多样性，使许多人怀疑是否有可能针对这种病毒进行有效的疫苗接种。但是，通过确定驱动艾滋病病毒持续多样化的选择性力量并表征其遗传后果，有可能设计出能够抢占某些更常见的逃避策略的疫苗。这种疫苗的一种成分可能是包膜蛋白gp41。除了被免疫系统的体液和细胞臂都靶向外，该蛋白还介导病毒和靶细胞膜之间的融合，并可能是HIV传播性的主要决定因素。

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期刊名称 Virology Journal
作者
Gama P Bandawe; Darren P Martin; Florette Treurnicht; Koleka Mlisana; Salim S Abdool Karim; Carolyn Williamson;
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年(卷),期 2008(5),-1
年度 2008
页码 141
总页数 16
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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专利

1. Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection [J] . Gama P Bandawe, Darren P Martin, Florette Treurnicht, Virology Journal . 2008,第1期

机译：跨多个亚型的gp41中保守的阳性选择信号以及在急性和慢性HIV-1亚型C感染期间采样的gp41序列中可检测到的选择信号差异
2. Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8 [J] . Sutar Jyoti, Padwal Varsha, Sonawani Archana, Virus Research: An International Journal of Molecular and Cellular Virology . 2019,第1期

机译：初级HIV-1印度亚型C序列近端外部区域对近中和抗体4E10和10E8的相互作用近外区域的影响
3. F(ab')2 fragment of a gp41 NHR-trimer-induced IgM monoclonal antibody neutralizes HIV-1 infection and blocks viral fusion by targeting the conserved gp41 pocket [J] . LuL., WeiM., ChenY., Microbes and infection . 2013,第13期

机译：gp41 NHR-三聚体诱导的IgM单克隆抗体的F（ab'）2片段通过靶向保守的gp41口袋来中和HIV-1感染并阻断病毒融合
4. A Feature Selection Algorithm for Detecting Subtype Specific Functional Sites from Protein Sequences for Smad Receptor Binding [C] . Elena Marchiori, Walter Pirovano, Jaap Heringa, International Conference on Machine Learning and Applications . 2006

机译：一种特征选择算法，用于检测蛋白质序列的亚型特异性功能位点对Smad受体结合的蛋白质序列
5. The functional relevance of multiple &alpha-2-adrenergic receptor subtypes in signaling and behavior. [D] . Schramm, Nicole Lewellyn. 2000

机译：多种α-2肾上腺素受体亚型在信号传导和行为中的功能相关性。
6. Selection with a Peptide Fusion Inhibitor Corresponding to the First Heptad Repeat of HIV-1 gp41 Identifies Two Genetic Pathways Conferring Cross-Resistance to Peptide Fusion Inhibitors Corresponding to the First and Second Heptad Repeats (HR1 and HR2) of gp41 [O] . Wei Wang, Christopher J. De Feo, Min Zhuang, 2011

机译：与HIV-1 gp41的第一个七肽重复序列对应的肽融合抑制剂的选择确定了两种遗传途径赋予与gp41的第一和第二个七肽重复序列（HR1和HR2）相对应的肽融合抑制剂交叉耐药性。
7. Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection [O] . Bandawe, Gama P, Martin, Darren P, Treurnicht, Florette, 2015

机译：跨多个亚型的gp41中保守的阳性选择信号以及在急性和慢性HIV-1亚型C感染期间采样的gp41序列中可检测到的选择信号差异

Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection

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