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首页> 美国卫生研究院文献>Virology Journal >Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou China 2009
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Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou China 2009

机译：2009年在中国广州的两种3型登革热病毒基因型的共同流通

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摘要

Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future.
机译：登革热正在成为世界上最重要的由蚊子传播的病毒性疾病。在中国大陆，已经有充分的证据证明由四种血清型登革热病毒（DENV-1至DENV-4）引起的零星和大规模的登革热暴发。广东省是中国的主要灾区，DENV-1在广东流传已久。在这项研究中，描述了广州的DENV-3感染的家庭簇。根据临床表现，血清学和RT-PCR分析，三例被诊断为登革热。在C6 / 36细胞中分离了两个DENV-3菌株，并确定了完整的基因组序列。系统发育分析表明，来自家族簇的新DENV-3分离株归为基因型III。考虑到2009年在广州也发现了V型基因中的多个DENV-3菌株，因此在广州共传播了至少两个DENV-3基因型。将来应进行仔细的调查和病毒学分析。

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