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Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice

机译：高滴度大流行H1N1血凝素和神经氨酸酶抗体的超免疫静脉免疫球蛋白可提供剂量依赖性保护抵抗SCID小鼠的致命病毒攻击

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摘要

BackgroundConvalescent plasma and fractionated immunoglobulins have been suggested as prophylactic or therapeutic interventions during an influenza pandemic.

机译：背景技术已提出恢复性血浆和分级免疫球蛋白可作为流感大流行期间的预防或治疗干预措施。

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期刊名称 Virology Journal
作者
Christine Hohenadl; Walter Wodal; Astrid Kerschbaum; Richard Fritz; M Keith Howard; Maria R Farcet; Daniel Portsmouth; John K McVey; Donald A Baker; Hartmut J Ehrlich; P Noel Barrett; Thomas R Kreil;
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年(卷),期 2014(11),-1
年度 2014
页码 70
总页数 6
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
H1N1 IVIG Influenza Intravenous immunoglobulin Passive transfer Neutralizing antibody Neuraminidase Hemagglutinin;

机译：H1N1;IVIG;流行性感冒;静脉免疫球蛋白;被动转移;中和抗体;神经氨酸酶;血凝素;

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专利

1. Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice [J] . Christine Hohenadl, Walter Wodal, Astrid Kerschbaum, Virology Journal . 2014,第1期

机译：含有高滴度大流行H1N1血凝素和神经氨酸酶抗体的超免疫静脉免疫球蛋白可提供剂量依赖性保护，以抵抗SCID小鼠的致命病毒攻击
2. Revisiting the 1976 "swine flu" vaccine clinical trials: cross-reactive hemagglutinin and neuraminidase antibodies and their role in protection against the 2009 H1N1 pandemic virus in mice. [J] . Xie H, Li X, Gao J, Clinical infectious diseases . 2011,第12期

机译：回顾1976年的“猪流感”疫苗临床试验：交叉反应性血凝素和神经氨酸酶抗体及其在小鼠中对抗2009 H1N1大流行性病毒的保护作用。
3. Revisiting the 1976 “Swine Flu” Vaccine Clinical Trials: Cross-reactive Hemagglutinin and Neuraminidase Antibodies and Theirn Role in Protection Against the 2009 H1N1 Pandemic Virus in Mice [J] . Zhiping Ye Clinical Infectious Diseases . 2011,第12期

机译：回顾1976年的“猪流感”疫苗临床试验：交叉反应性血凝素和神经氨酸酶抗体及其在小鼠2009 H1N1大流行性病毒中的保护作用
4. Functional Interplay between Hemagglutinin and Neuraminidase of Pandemic 2009 H1N1 from the Perspective of Virus Evolution [C] . Wei Hu International symposium on bioinformatics research and applications . 2014

机译：从病毒进化的角度看大流行2009 H1N1血凝素和神经氨酸酶之间的功能相互作用
5. Characterization of vaccine-associated enhanced respiratory disease (VAERD) in swine administered an inactivated delta-cluster influenza vaccine and challenged with pandemic A/H1N1 virus. [D] . Gauger, Phillip C. 2012

机译：接种灭活的δ-集群流感疫苗并受到大流行A / H1N1病毒攻击的猪中与疫苗相关的增强呼吸道疾病（VAERD）的特征。
6. Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice [O] . Judith D. Easterbrook, Louis M. Schwartzman, Jin Gao, -1

机译：防止致命的H5N1型流感的挑战滴鼻免疫与病毒样含在小鼠2009年甲型H1N1流感神经氨酸酶颗粒
7. Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice [O] . Christine Hohenadl, Walter Wodal, Astrid Kerschbaum, 2014

机译：高滴度大流行H1N1血凝素和神经氨酸酶抗体的超免疫静脉免疫球蛋白可提供剂量依赖性保护，抵抗SCID小鼠的致命病毒攻击

Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice

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