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Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way?

机译：税收的抗凋亡作用：NF-κB途径还是CREB途径？

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The NF-κB pathway is intimately linked to the survival of mammalian cells, and its activation by Tax has consequently been considered important for human T-cell leukemia/lymphoma virus type 1 (HTLV-1)-infected cell resistance to death. Very little emphasis has been given to other mechanisms, although Tax regulates the expression and activity of several cellular genes. The finding that CREB protein is activated in HTLV-1 infected cells underlines the possibility that other mechanisms of survival may be implicated in HTLV-1 infection. Indeed, CREB activation or overexpression plays a role in normal hematopoiesis, as well as in leukemia development, and CREB is considered as a survival factor in various cell systems. A better understanding of the different molecular mechanisms used by Tax to counteract cell death will also help in the development of new therapeutic strategies for HTLV-1 associated diseases.

机译：NF-κB通路与哺乳动物细胞的生存密切相关，因此，其被Tax激活被认为对人类T细胞白血病/淋巴瘤病毒1型（HTLV-1）感染的细胞死亡具有重要意义。尽管Tax调节几种细胞基因的表达和活性，但对其他机制的关注却很少。 CREB蛋白在HTLV-1感染的细胞中被激活的发现强调了其他生存机制可能与HTLV-1感染有关的可能性。实际上，CREB的激活或过表达在正常的造血以及白血病的发展中起作用，并且CREB被认为是各种细胞系统中的存活因子。对Tax用于抵消细胞死亡的不同分子机制的更好理解也将有助于开发HTLV-1相关疾病的新治疗策略。

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期刊名称 Viruses
作者
Daniela Saggioro;
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作者单位

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年(卷),期 2011(3),7
年度 2011
页码 1001–1014
总页数 14
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
HTLV-1 tax apoptosis NF-κB PI3K/Akt Ras ERK CREB;

机译：HTLV-1;税;凋亡;NF-κB;PI3K / Akt;Ras;ERK;CREB;

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专利

1. Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way? [J] . Daniela Saggioro Viruses . 2011,第7期

机译：税收的抗凋亡作用：NF-κB途径还是CREB途径？
2. MiR-582-5p/miR-590-5p targeted CREB1/CREB5–NF-κB signaling and caused opioid-induced immunosuppression in human monocytes [J] . X Long, Y Li, S Qiu, Translational psychiatry. . 2016,第3期

机译：MiR-582-5p / miR-590-5p靶向CREB1 /CREB5-NF-κB信号传导并引起阿片样物质诱导的人类单核细胞免疫抑制
3. NF-κB and Enhancer-binding CREB Protein Scaffolded by CREB-binding Protein (CBP)/p300 Proteins Regulate CD59 Protein Expression to Protect Cells from Complement Attack [J] . Yiqun Du, Xiaoyan Teng, Na Wang, The Journal of biological chemistry . 2014,第5期

机译：通过Creb结合蛋白（CBP）/ P300蛋白的NF-κB和增强剂结合CREB蛋白调节CD59蛋白表达以保护细胞免受补体攻击
4. Epigallocatechin Gallate Inhibits Phorbol Ester-Induced Activation of NF-κB and CREB in Mouse Skin Role of p38 MAPK [C] . JOYDEB KUMAR KUNDU, YOUNG-JOON SURH Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：表没食子儿茶素没食子酸酯抑制佛波酯诱导的NF-κB和CREB活化在小鼠皮肤中的作用p38 MAPK
5. The path to earned income tax credit participation: Are community coalitions beneficial? [D] . Campos, Nora. 2014

机译：获得所得税抵免的途径：社区联盟是否有益？
6. Expansion of CREBs DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB. [O] . N Adya, L J Zhao, W Huang, 1994

机译：通过Tax扩展CREB的DNA识别特异性是由于与CREB保守DNA结合结构域附近的282-284位的Ala-Ala-Arg相互作用。
7. Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way? [O] . Saggioro, Daniela 2011

机译：税收的抗凋亡作用：NF-κB途径还是CREB途径？

Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way?

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