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首页> 美国卫生研究院文献>Viruses >New Insights into the Evolutionary and Genomic Landscape of Molluscum Contagiosum Virus (MCV) based on Nine MCV1 and Six MCV2 Complete Genome Sequences
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New Insights into the Evolutionary and Genomic Landscape of Molluscum Contagiosum Virus (MCV) based on Nine MCV1 and Six MCV2 Complete Genome Sequences

机译：基于九个MCV1和六个MCV2完整基因组序列的传染性软体动物感染和进化的新见解

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Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). In comparison to MCV1, a higher degree of nucleotide sequence conservation was observed among MCV2 genomes. Large-scale recombination events were identified in two newly assembled MCV1 genomes and one MCV2 genome. One recombination event was located in a newly identified recombinant region of the viral genome, and all previously described recombinant regions were re-identified in at least one novel MCV genome. MCV genes comprising the identified recombinant segments have been previously associated with viral interference with host T-cell and NK-cell immune responses. In conclusion, the two most common MCV genotypes emerged along divergent evolutionary pathways from a common ancestor, and the differences in the heterogeneity of MCV1 and MCV2 populations may be attributed to the strictness of the constraints imposed by the host immune response.
机译：传染性软体动物是软体动物的唯一成员，也是常见的皮肤病传染性软体动物的致病因子。尽管它是一种重要且常见的人类病原体，但其遗传景观和进化史仍然未知。在这项研究中，确定了两种最常见的MCV基因型的十个新颖的完整MCV基因组序列（五个MCV1和五个MCV2序列），并与先前存放在可自由访问的序列存储库中的所有MCV完整基因组（四个MCV1和一个MCV2）一起进行了分析。与MCV1相比，在MCV2基因组中观察到更高程度的核苷酸序列保守性。在两个新组装的MCV1基因组和一个MCV2基因组中鉴定出大规模重组事件。一个重组事件位于病毒基因组的新鉴定的重组区中，并且在至少一个新的MCV基因组中重新鉴定了所有先前描述的重组区。包含已鉴定的重组区段的MCV基因先前已与病毒对宿主T细胞和NK细胞免疫反应的干扰有关。总之，两种最常见的MCV基因型沿着共同祖先的不同进化途径出现，MCV1和MCV2群体异质性的差异可能归因于宿主免疫应答施加的约束的严格性。

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