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Don’t Shut the Stable Door after the Phage Has Bolted—The Importance of Bacteriophage Inactivation in Food Environments

机译:噬菌体破裂后不要关闭稳定的门—噬菌体灭活在食物环境中的重要性

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摘要

In recent years, a new potential measure against foodborne pathogenic bacteria was rediscovered—bacteriophages. However, despite all their advantages, in connection to their widespread application in the food industry, negative consequences such as an uncontrolled phage spread as well as a development of phage resistant bacteria can occur. These problems are mostly a result of long-term persistence of phages in the food production environment. As this topic has been neglected so far, this article reviews the current knowledge regarding the effectiveness of disinfectant strategies for phage inactivation and removal. For this purpose, the main commercial phage products, as well as their application fields are first discussed in terms of applicable inactivation strategies and legal regulations. Secondly, an overview of the effectiveness of disinfectants for bacteriophage inactivation in general and commercial phages in particular is given. Finally, this review outlines a possible strategy for users of commercial phage products in order to improve the effectiveness of phage inactivation and removal after application.
机译:近年来,重新发现了一种针对食源性致病细菌的新潜在措施-噬菌体。然而,尽管它们具有所有优点,但与其在食品工业中的广泛应用相关,却可能发生负面后果,例如不受控制的噬菌体扩散以及产生噬菌体抗性细菌。这些问题主要是由于噬菌体在食品生产环境中长期存在造成的。到目前为止,由于这个话题已被忽略,因此本文回顾了有关噬菌体灭活和去除消毒策略有效性的最新知识。为此,首先根据适用的灭活策略和法律法规来讨论主要的商业噬菌体产品及其应用领域。其次,概述了消毒剂对一般和商业噬菌体灭活噬菌体的有效性。最后,本综述概述了商业噬菌体产品使用者的可能策略,以提高应用后噬菌体灭活和去除的有效性。

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