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首页> 美国卫生研究院文献>World Journal of Gastroenterology >A comparison between Zhishi Xiaopiwan and cisapride in treatment of functional dyspepsia
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A comparison between Zhishi Xiaopiwan and cisapride in treatment of functional dyspepsia

机译：止食消脾丸与西沙必利治疗功能性消化不良的比较

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AIM: To compare the therapeutic effect of the herbal medicine Zhishi Xiaopi with that of Cisapride in the treatment of functional dyspepsia (FD).METHODS: Fifty-one FD patients were randomized into Herbal group (n = 27) and Cisapride group (n = 24). Two two groups were given a four-week treatment of Zhishi Xiaopiwan 100 mL, tid, a.c. and Cisapride 5 mg, tid, a.c. respectively. Patients’ symptoms were assessed and 39 patients’ (22 of Herbal group and 17 of Cisapride group) gastric liquid emptying times were measured with ultrasonography before and after the treatment.RESULTS: The therapeutic effective rates of Herbal group and Cisapride group were 81.49% and 87.50% (P > 0.05). The half gastric emptying time (GET50) and gastric emptying time (GET) of healthy controls and FD patients were 36.12 min ± 10.22 min vs 52.95 min ± 13.49 min and 87.07 min ± 21.11 min vs 120.74 min ± 23.08 min (P < 0.001). The GET50 and GET of Herbal group before and after the treatment were 51.63 min ± 13.15 min vs 45.62 min ± 10.82 min and 117.34 min ± 23.29 min vs 103.26 min ± 22.19 min (P < 0.01). The results of Cisapride group were 54.66 min ± 14.14 min vs 40.95 min ± 11.29 min and 125.12 min ± 24.47 min vs 95.49 min ± 22.31 min (P < 0.01). The differences in values (median) of GET50 and GET for Herbal group and Cisapride group before and after treatment were 5.75 min vs 17.18 min and 13.22 min vs 33.54 min (P < 0.05).CONCLUSION: Delayed gastric emptying is one of the pathogenesis of FD. Both Zhishi Xiaopi pills and Cisapride can effectively alleviate the symptoms of FD and accelerate gastric liquid emptying. The effect of Zhishi Xiaopiwan on enhancing gastric motility is comparable with but less than that of Cisapride.
机译：目的：比较中药智实消皮与西沙必利治疗功能性消化不良（FD）的疗效。方法：将51例FD患者随机分为中药组（n = 27）和西沙必利组（n =）。 24）。两组分别接受治志小皮丸100 mL，每日两次A.C.西沙必利5毫克，每日一次分别。治疗前后对患者症状进行评估，并用超声检查39例患者（中药组22例，西沙必利组17例）的胃液排空时间。结果：中药组和西沙必利组的治疗有效率为81.49％。 87.50％（P> 0.05）。健康对照者和FD患者的半数胃排空时间（GET50）和胃排空时间（GET）为36.12分钟±10.22分钟vs 52.95分钟±13.49分钟和87.07分钟±21.11分钟vs 120.74分钟±23.08分钟（P <0.001） 。草药组治疗前后的GET50和GET为51.63 min±13.15 min，而45.62 min±10.82 min和117.34 min±23.29 min vs 103.26 min±22.19 min（P <0.01）。西沙必利组的结果为54.66分钟±14.14分钟vs 40.95分钟±11.29分钟和125.12分钟±24.47分钟vs 95.49分钟±22.31分钟（P <0.01）。草药组和西沙必利组治疗前后GET50和GET值的差异（中位数）为5.75 min vs. 17.18 min和13.22 min vs 33.54 min（P <0.05）。结论：胃排空延迟是其发病机制之一。 FD。止食消脾丸和西沙必利均可有效缓解FD症状，加速胃液排空。止食消脾丸对增强胃动力的作用与西沙必利相当，但少于西沙必利。

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