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Achieving UNAIDS 90-90-90 targets for pregnant and postpartum women in sub-Saharan Africa: progress gaps and research needs

机译:实现联合国艾滋病规划署90-90-90怀孕目标和撒哈拉以南非洲的产后妇女:进展差距和研究需求

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摘要

The implementation of the 2013 World Health Organization Option B+ recommendations for HIV treatment during pregnancy has helped drive significant progress in achieving universal treatment for pregnant and postpartum women in sub-Saharan Africa (SSA). Yet, critical research and implementation gaps exist in achieving the UNAIDS 90-90-90 targets. To help guide researchers, programmers and policymakers in prioritising these areas, we undertook a comprehensive review of the progress, gaps and research needs to achieve the 90-90-90 targets for this population in the Option B+ era, including early infant HIV diagnosis (EID) for HIV-exposed infants. Salient areas where progress has been achieved or where gaps remain include: (1) knowledge of HIV status is higher among people with HIV in southern and eastern Africa compared to western and central Africa (81% versus 48%, UNAIDS); (2) access to antiretroviral therapy (ART) for pregnant women has doubled in 22 of 42 SSA countries, but only six have achieved the second 90, and nearly a quarter of pregnant women initiating ART become lost to follow-up; (3) viral suppression data for this population are sparse (estimates range from 30% to 98% peripartum), with only half of women maintaining suppression through 12 months postpartum; and (4) EID rates range from 15% to 62%, with only three of 21 high-burden SSA countries testing >50% HIV-exposed infants within the first 2 months of life. We have identified and outlined promising innovations and research designed to address these gaps and improve the health of pregnant and postpartum women living with HIV and their infants.
机译:2013年世界卫生组织关于怀孕期间艾滋病毒治疗的备选方案B +建议的实施,有助于在实现撒哈拉以南非洲(SSA)孕妇和产后妇女的普遍治疗方面取得重大进展。然而,在实现联合国艾滋病规划署90-90-90目标方面存在重大的研究和实施差距。为了帮助指导研究人员,程序员和政策制定者确定这些领域的优先级,我们全面审查了在Option B +时代实现该人群90-90-90目标(包括早期婴儿HIV诊断)的进展,差距和研究需求。 EID)暴露于HIV的婴儿。取得进展或仍存在差距的突出领域包括:(1)与南部非洲和中部非洲相比,南部和东部非洲的艾滋病毒感染者对艾滋病毒状况的了解更高(联合国艾滋病规划署为81%,而48%); (2)在42个SSA国家中,有22个国家的孕妇获得抗逆转录病毒疗法(ART)的人数增加了一倍,但在第二个90个国家中,只有六个国家获得了抗逆转录病毒疗法(ART),而将近四分之一的发起抗逆转录病毒疗法的孕妇失去了随访; (3)该人群的病毒抑制数据稀疏(估计围产期为30%至98%),只有一半的妇女在产后12个月保持抑制。 (4)EID发生率介于15%至62%之间,在21个负担沉重的撒哈拉以南非洲国家中,只有三个国家在出生后的前两个月内对暴露于HIV的婴儿进行了50%以上的检测。我们已经确定并概述了有前途的创新和研究,旨在解决这些差距并改善感染艾滋病毒及其婴儿的孕妇和产后妇女的健康。

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