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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Intestinal permeability in patients after surgical trauma and effect of enteral nutrition versus parenteral nutrition
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Intestinal permeability in patients after surgical trauma and effect of enteral nutrition versus parenteral nutrition

机译：手术创伤后患者的肠通透性及肠内营养与肠外营养的关系

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AIM: To study the intestinal permeability (IP) following stress of abdominal operation and the different effects on IP of enteral nutrition (EN) and parenteral nutrition (PN).METHODS: Forty patients undergoing abdominal surgery were randomized into EN group and PN group. Each group received nutritional support of the same nitrogen and calorie from postoperative day (POD) 3 to POD 11. On the day before operation (POD-1), POD 7 and POD 12, 10 g of lactulose and 5 g of mannitol were given orally, and urine was collected for 6 hours. Urine excretion ratios of lactulose and mannitol (L/M) were measured.RESULTS: L/M ratios of EN group on POD-1, POD 7 and POD 12 were 0.026 ± 0.017, 0.059 ± 0.026, 0.027 ± 0.017, respectively, and those of PN group were 0.025 ± 0.013, 0.080 ± 0.032, 0.047 ± 0.021, respectively. Patients of both groups had elevated L/M ratios on POD 7 vs. POD-1. However the ratio returned toward control level in EN group by POD 12. In contrast, PN group still had elevated L/M ratios on POD 12.CONCLUSION: L/M ratio increases for a period of time after surgical trauma and the loss of gut mucosal integrity can be reversed by substitution of enteral nutrition.
机译：目的：研究腹部手术压力对肠道通透性（IP）的影响以及肠内营养（EN）和肠胃外营养（PN）对IP的影响。方法：将40例行腹部手术的患者随机分为EN组和PN组。从术后第3天到第11天，每组都接受相同氮和卡路里的营养支持。在手术前一天（POD-1），POD 7和POD 12，给予10克乳果糖和5克甘露醇。口服，收集尿液6小时。结果：EN组在POD-1，POD 7和POD 12上的L / M比分别为0.026±0.017、0.059±0.026、0.027±0.017和（L / M）。 PN组分别为0.025±0.013、0.080±0.032、0.047±0.021。两组患者的POD 7相对于POD-1的L / M比均升高。然而，POD 12使EN组的比例恢复到对照组水平。相比之下，PN组在POD 12上的L / M比例仍然升高。结论：手术创伤和肠道损失后一段时间内L / M比例增加。粘膜完整性可通过替代肠内营养而逆转。

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