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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Expression of a novel immunoglobulin gene SNC73 in human cancer and non-cancerous tissues
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Expression of a novel immunoglobulin gene SNC73 in human cancer and non-cancerous tissues

机译：新型免疫球蛋白基因SNC73在人类癌症和非癌组织中的表达

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AIM: To investigate the expression of immunoglobulin gene SNC73 in malignant tumors and non-cancerous normal tissues.METHODS: Expression level of SNC73 in tumors and non-cancerous tissues from the same patient was determined by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay (RT-PCR-ELISA) in 90 cases of malignant tumors, including colorectal cancer, gastric cancer, breast cancer, lung cancer and liver cancer. Analysis on the correlation of SNC73 expression with sex, age, site, grade of differentiation, depth of invasion, and metastases in colorectal cancer patients was made.RESULTS: Expression level of SNC73 in non-cancerous colorectal mucosa and colorectal cancerous tissues was 1.234 ± 0.842 and 0.737 ± 0.731, respectively (P < 0.01), with the mean ratio of 7.134 ± 14.092 (range, 0.36-59.54). Expression of SNC73 showed no significant difference among gastric cancer, breast cancer, lung cancer and liver cancer when compared with non-cancerous tissues (P > 0.05). No correlation was found between SNC73 expression level and various clinicopathological factors, including sex, age, site, grade of differentiation, depth of invasion and metastases of CRC patients.CONCLUSION: Down-regulation of SNC73 expression may be a relatively specific phenomenon in colorectal cancer. SNC73 is a potential genetic marker for the carcinongenesis of colorectal cancer. The relationship of SNC73 expression and carcinogenesis of colorectal cancer merits further study.
机译：目的：探讨免疫球蛋白基因SNC73在恶性肿瘤和非癌性正常组织中的表达。方法：通过逆转录聚合酶链反应和酶联免疫吸附法测定同一患者的肿瘤和非癌性组织中SNC73的表达水平。检测（RT-PCR-ELISA）检测90例恶性肿瘤，包括大肠癌，胃癌，乳腺癌，肺癌和肝癌。分析了SNC73表达与大肠癌患者的性别，年龄，部位，分化程度，浸润深度和转移的相关性。结果：SNC73在非癌性大肠黏膜和大肠癌组织中的表达水平为1.234±分别为0.842和0.737±0.731（P <0.01），平均比率为7.134±14.092（范围0.36-59.54）。与非癌组织相比，SNC73的表达在胃癌，乳腺癌，肺癌和肝癌中无显着差异（P> 0.05）。 SNC73表达水平与CRC患者的性别，年龄，部位，分化程度，浸润深度和转移等临床病理因素之间无相关性。结论：SNC73表达下调可能是结直肠癌的一种相对特异性现象。 。 SNC73是结肠直肠癌致癌的潜在遗传标记。 SNC73表达与大肠癌发生的关系值得进一步研究。

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