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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease
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Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease

机译：抗反流治疗对哮喘胃食管反流病患者支气管高反应性和肺功能的影响

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AIM: To investigate the effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease (GERD).METHODS: Thirty asthmatic patients with GERD were randomly divided into two groups (group A and group B). Patients in group A (n = 15) only received asthma medication including inhaled salbutamol 200 μg four times a day and budesonide 400 μg twice a day for 6 weeks. Patients in Group B (n = 15) received the same medication as group A, and also antireflux therapy including oral omeprazole 20 mg once a day and domperidone 10 mg three times a day for 6 weeks. Pulmonary function tests and histamine bronchoprovocation test were performed before and after the study.RESULTS: There was no significant difference in the baseline values of pulmonary function and histamine PC20-FEV1 between the two groups. At the end of the study, the mean values for VC, VC%, FVC, FVC%, FEV1, FEV1%, PEF, PEF%, PC20-FEV1 were all significantly improved in group B, compared withgroup A.CONCLUSION: Antireflux therapy may improve pulmonary function and inhibit bronchial hyper-responsiveness in asthmatic patients with GERD.
机译：目的：探讨抗反流治疗对哮喘胃食管反流病（GERD）患者支气管高反应性和肺功能的影响。方法：将30例GERD哮喘患者随机分为两组（A组和B组）。 A组（n = 15）的患者仅接受哮喘药物治疗，包括每天四次吸入200克沙丁胺醇和布地奈德每天两次400克，持续6周。 B组（n = 15）的患者接受与A组相同的药物治疗，还接受抗反流治疗，包括每天一次口服奥美拉唑20 mg和每天3次多潘立酮10 mg，共6周。研究前后进行了肺功能检查和组胺支气管激发试验。结果：两组肺功能和组胺PC20-FEV1的基线值无显着差异。在研究结束时，与A组相比，B组的VC，VC％，FVC，FVC％，FEV1，FEV1％，PEF，PEF％，PC20-FEV1的平均值均得到了明显改善。可能改善哮喘GERD患者的肺功能并抑制支气管高反应性。

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