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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough: A comparison between two different daily doses of lansoprazole
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Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough: A comparison between two different daily doses of lansoprazole

机译：质子泵抑制剂治疗胃食管反流相关性慢性咳嗽的患者：兰索拉唑两种不同日剂量的比较

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AIM: To compare two different daily doses of lansoprazole given for 12 weeks and to assess the role of gastrointestinal (GI) investigations as criteria for selecting patients.METHODS: Out of 45 patients referred for unexplained chronic persistent cough, 36 had at least one of the GI investigations (endoscopy, 24-h esophageal pH-metry and a 4-week trial of proton pump inhibitor (PPI) therapy) positive and were randomly assigned to receive either 30 mg lansoprazole o.d. or 30 mg lansoprazole b.i.d. for 12 weeks. Symptoms were evaluated at baseline (visit 1) after the PPI test (visit 2) and after the 12-week lansoprazole treatment period (visit 3).RESULTS: Thirty-five patients completed the study protocol. Twenty-one patients (60.0%) reported complete relief from their cough with no difference between the two treatment groups (58.8% and 61.1% had no cough in 30 mg lansoprazole and 60 mg lansoprazole groups, respectively). More than 80% of the patients who had complete relief from their cough at the end of the treatment showed a positive response to the PPI test.CONCLUSION: Twelve weeks of lansoprazole treatment even at a standard daily dose, is effective in patients with chronic persistent cough. A positive response to an initial PPI test seems to be the best criterion for selecting patients who respond to therapy.
机译：目的：比较兰索拉唑的两种不同每日剂量，持续12周，并评估胃肠道（GI）检查作为选择患者的标准。方法：在45位因无法解释的慢性持续性咳嗽转诊的患者中，有36位至少有以下1位胃肠道检查（内窥镜检查，24小时食管pH测量和质子泵抑制剂（PPI）治疗的4周试验）为阳性，并随机分配接受30毫克兰索拉唑或或30毫克兰索拉唑b.i.d.持续12周。在PPI测试后（访视2）和兰索拉唑治疗12周（访视3）后，在基线（访视1）评估症状。结果：35名患者完成了研究方案。 21名患者（60.0％）称其咳嗽完全缓解，两个治疗组之间无差异（30 mg lansoprazole和60 mg lansoprazole组分别无咳嗽）分别为58.8％和61.1％。在治疗结束后完全缓解咳嗽的患者中，超过80％的患者对PPI测试表现出阳性反应。结论：即使以标准的每日剂量服用12周的兰索拉唑，对于慢性持续性疾病患者也有效咳嗽。对初始PPI测试的阳性反应似乎是选择对治疗有反应的患者的最佳标准。

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