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Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy

机译：PPI和H2RA对阿司匹林连续治疗期间溃疡的疗效比较研究

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AIM: To compare the therapeutic effects of proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) on gastroduodenal ulcers under continuous use of low-dose aspirin.METHODS: Sixty patients who had a gastroduodenal ulcer on screening endoscopy but required continuous use of low-dose aspirin were randomly assigned to receive PPI (lansoprazole 30 mg, n = 30) or H2RA (famotidine 40 mg or if famotidine had been administered before assignment, ranitidine 300 mg, n = 30). The therapeutic effects were evaluated by endoscopy after 8-wk treatment. The presence or absence of Helicobacter pylori (H. pylori) was determined by urea breath test before treatment. Abdominal symptoms were compared with the gastrointestinal symptom rating scale (GSRS) questionnaire before and after treatment.RESULTS: Twenty-six patients in the PPI group and 26 patients in the H2RA group, excluding dropouts, were analyzed. There were no significant differences in median age, sex, underlying disease, smoking status, H. pylori infection, prevalence of ulcers before treatment, and lesion site between the two groups. The therapeutic effects were endoscopically evaluated as healed in 23 patients (88.5%) and not healed in 3 patients in the PPI group and as healed in 22 patients (84.6%) and not healed in 4 patients in the H2RA group. Abdominal symptoms before treatment were uncommon in both groups; the GSRS scores were not significantly reduced after treatment as compared with before treatment.CONCLUSION: The healing rate of gastroduodenal ulcers during continuous use of low-dose aspirin was greater than 80% in both the PPI group and the H2RA group, with no significant difference between the two groups.
机译：目的：比较质子泵抑制剂（PPI）和组胺2受体拮抗剂（H2RA）在连续使用低剂量阿司匹林的情况下对十二指肠溃疡的治疗效果。方法：60例在筛查胃镜但患有十二指肠溃疡但需要连续使用的患者低剂量的阿司匹林随机分配接受PPI（兰索拉唑30 mg，n = 30）或H2RA（法莫替丁40 mg或如果在分配前已服用法莫替丁，雷尼替丁300 mg，n = 30）。 8周治疗后通过内窥镜评估疗效。治疗前通过尿素呼气试验确定是否存在幽门螺杆菌（H. pylori）。结果：对PPI组26例患者和H2RA组26例患者进行治疗前后腹部症状与胃肠道症状分级量表（GSRS）的比较。两组之间的中位年龄，性别，基础疾病，吸烟状况，幽门螺杆菌感染，治疗前溃疡患病率和病变部位无显着差异。内窥镜下评估治疗效果：PPI组中有23例（88.5％）and愈，PPI组中有3例没有not愈； H2RA组在22例（84.6％）中and愈了。两组治疗前的腹部症状均不常见。结论：PPI组和H2RA组连续使用小剂量阿司匹林期间胃十二指肠溃疡的治愈率均高于80％，差异无统计学意义。两组之间。

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