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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Effect of domperidone therapy on nocturnal dyspeptic symptoms of functional dyspepsia patients
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Effect of domperidone therapy on nocturnal dyspeptic symptoms of functional dyspepsia patients

机译：多潘立酮治疗对功能性消化不良患者夜间消化不良症状的影响

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AIM: To investigate the incidence of nocturnal dyspeptic symptoms in patients with functional dyspepsia (FD) and whether prokinetic drugs can alleviate them.METHODS: Eighty-five consecutive Chinese patients with FD were included in this study. One week after single-blinded placebo run-in treatment, baseline nocturnal intragastric pH, bile reflux and nocturnal dyspeptic symptoms of eligible patients, including epigastric pain or discomfort, abdominal distention and belching, were investigated with questionnaires. Patients exhibiting nocturnal dyspeptic symptoms were randomly and double-blindly assigned to domperidone group or placebo group. Nocturnal intragastric pH and percentage of duodenogastric bile reflux time were determined after treatment.RESULTS: Of the 85 FD patients, 2 females without nocturnal symptoms, who responded to placebo run-in treatment, were excluded from the study, 30 (36.1%) exhibited nocturnal dyspeptic symptoms with increased duodenogastric bile reflux time (intragastric bilirubin absorbance > 0.14) and mean gastric pH (confirming the existence of bile reflux) (P = 0.021, 0.023) at night were included in the study. Of these 30 patients, 21 (70%) had overt nocturnal duodenogastric bile reflux, which was significantly higher than that of those without nocturnal symptoms (P = 0.026). The 30 patients were allocated to domperidone group or placebo group (n = 15). The nocturnal duodenogastric bile reflux and gastric pH were significantly decreased after domperidone treatment (P = 0.015, 0.021). The severity score of nocturnal dyspeptic symptoms was also significantly decreased after domperidone treatment (P = 0.010, 0.015, 0.026), which was positively correlated with the reduced nocturnal bile reflux or gastric pH (r = 0.736, 0.784, 0.753 or r = 0.679, 0.715, 0.697, P = 0.039, 0.036, 0.037 or P = 0.043, 0.039, 0.040).CONCLUSION: A subgroup of Chinese FD patients show overt nocturnal dyspeptic symptoms, which may be correlated with the excessive nocturnal duodenogastric bile reflux. Domperidone therapy can alleviate these symptoms.
机译：目的：探讨功能性消化不良（FD）患者的夜间消化不良症状的发生率以及促动力药物是否能缓解这些症状。方法：本研究纳入了八十五名连续的中国FD患者。单盲安慰剂磨合治疗一周后，通过问卷调查了符合条件的患者的基线夜间胃内pH值，胆汁反流和夜间消化不良症状，包括上腹痛或不适，腹胀和bel气。表现出夜间消化不良症状的患者被随机双盲分配至多潘立酮组或安慰剂组。治疗后确定夜间胃内pH和十二指肠胆汁反流时间百分比。结果：在85名FD患者中，有2例无夜间症状的女性对安慰剂磨合治疗有反应，被排除在研究之外，其中30例（36.1％）出现夜间消化不良症状包括十二指肠胃胆汁反流时间增加（胃内胆红素吸收> 0.14）和夜间平均胃pH（证实存在胆汁反流）（P = 0.021，0.023）。在这30例患者中，有21例（70％）有明显的夜间十二指肠胆汁反流，这明显高于没有夜间症状的患者（P = 0.026）。 30例患者被分为多潘立酮组或安慰剂组（n = 15）。多潘立酮治疗后夜间十二指肠胃胆汁反流和胃pH值显着降低（P = 0.015，0.021）。多潘立酮治疗后，夜间消化不良症状的严重程度评分也显着降低（P = 0.010、0.015、0.026），这与夜间胆汁反流或胃液pH降低呈正相关（r = 0.736、0.784、0.753或r = 0.679， 0.715，0.697，P = 0.039，0.036，0.037或P = 0.043，0.039，0.040）。结论：一部分中国FD患者表现出明显的夜间消化不良症状，这可能与夜间十二指肠胃反流过多有关。多潘立酮疗法可以缓解这些症状。

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