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Recent developments in optimal experimental designs for functional magnetic resonance imaging

机译:功能性磁共振成像最佳实验设计的最新进展

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摘要

Functional magnetic resonance imaging (fMRI) is one of the leading brain mapping technologies for studying brain activity in response to mental stimuli. For neuroimaging studies utilizing this pioneering technology, there is a great demand of high-quality experimental designs that help to collect informative data to make precise and valid inference about brain functions. This paper provides a survey on recent developments in experimental designs for fMRI studies. We briefly introduce some analytical and computational tools for obtaining good designs based on a specified design selection criterion. Research results about some commonly considered designs such as blocked designs, and m-sequences are also discussed. Moreover, we present a recently proposed new type of fMRI designs that can be constructed using a certain type of Hadamard matrices. Under certain assumptions, these designs can be shown to be statistically optimal. Some future research directions in design of fMRI experiments are also discussed.
机译:功能磁共振成像(fMRI)是研究脑部活动对精神刺激作出反应的领先脑部绘图技术之一。对于利用这种开创性技术的神经影像学研究,对高质量实验设计的需求很大,这些实验设计有助于收集有用的数据,以对大脑功能进行准确而有效的推断。本文提供了有关功能磁共振成像研究实验设计最新进展的调查。我们简要介绍一些用于根据指定的设计选择标准来获得良好设计的分析和计算工具。还讨论了有关某些常用设计的研究结果,例如封闭设计和m序列。此外,我们提出了一种最近提出的新型fMRI设计,可以使用某种类型的Hadamard矩阵进行构建。在某些假设下,可以证明这些设计在统计上是最优的。还讨论了功能磁共振成像实验设计中的一些未来研究方向。

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