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首页> 美国卫生研究院文献>Cytotechnology >The role of natural indigo dye in alleviation of genotoxicity of sodium dithionite as a reducing agent
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The role of natural indigo dye in alleviation of genotoxicity of sodium dithionite as a reducing agent

机译：天然靛蓝染料在减轻连二亚硫酸钠作为还原剂的遗传毒性中的作用

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摘要

Indigo blue is a natural dye used for thousands of years by civilizations to dye fabric blue and it is naturally obtained from Isatis tinctoria. I. tinctoria is not only used for extraction of indigo blue color but also used medicinally in Traditional Chinese Medicine because of its active compounds. Sodium dithionite (Na2S2O4) is used in dye bath for indigo blue extraction, but this reducing agent and its derivatives are major pollutants of textile industry and subsequently have hazardous influences on public health. Herein, the present study was designed to obtain the high yield of natural indigo dye but with low possible toxic effect. In this context, genotoxic effects of particular combinations of natural dye solutions obtained from Isatis tinctoria subsp. tomentolla with Na2S2O4 as reducing agent were investigated. Dye solutions were obtained using two different pH levels (pH 9 and 11) and three different concentrations of Na2S2O4 (2.5, 5 and 10 mg/ml). In addition to the dye solutions and reducing agent, aqueous extracts of I. tinctoria were assessed for their genotoxicity on human lymphocytes. For in vitro testing of genotoxicity, chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and mitotic indexes (MI) assays were used. Accordingly, Na2S2O4 caused significant increases in CA and SCE as well decrease in MI but the genotoxic effects of sodium dithionite were reduced with natural indigo dye. As a result, aqueous extracts of Isatis leaves removed the toxic effects of sodium dithionite and showed anti-genotoxic effect. For the optimal and desired quality but with less toxic effects of natural dye, 2.5 mg/ml (for wool yarn) and 5 mg/ml (for cotton yarn) of Na2S2O4 doses were found to be the best doses for reduction in the dye bath at Ph 9.
机译：靛蓝是一种文明的天然染料，已有数千年的历史，被文明用来染色织物蓝色，它是从Isatis tinctoria天然获得的。 I. tinctoria不仅用于提取靛蓝，而且由于其活性成分，还可以在中药中药用。连二亚硫酸钠（Na2S2O4）用于染浴中以靛蓝萃取，但这种还原剂及其衍生物是纺织工业的主要污染物，因此对公众健康产生有害影响。本文中，本研究旨在获得高收率的天然靛蓝染料，但毒性较低。在这种情况下，从板蓝根亚种获得的天然染料溶液的特定组合的遗传毒性作用。研究了以Na2S2O4为还原剂的托门酚。使用两种不同的pH值（pH 9和11）和三种不同浓度的Na2S2O4（2.5、5和10 mg / ml）获得染料溶液。除染料溶液和还原剂外，还评估了紫丁香水提取物对人淋巴细胞的遗传毒性。为了进行遗传毒性的体外测试，使用了染色体畸变（CA），姐妹染色单体交换（SCE）和有丝分裂指数（MI）分析。因此，Na 2 S 2 O 4引起CA和SCE的显着增加以及MI的降低，但是天然靛蓝染料降低了连二亚硫酸钠的遗传毒性作用。结果，板蓝叶的水提物去除了连二亚硫酸钠的毒性作用并显示出抗遗传毒性作用。为了获得最佳和理想的质量，但对天然染料的毒性较小，发现2.5 mg / ml（对于羊毛纱）和5 mg / ml（对于棉纱）的Na2S2O4剂量是减少染浴的最佳剂量在Ph 9。

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