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首页> 美国卫生研究院文献>Data in Brief >Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief
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Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief

机译：D. melanogaster的性别特异性适应性稳态取决于20S蛋白酶体增加的蛋白水解作用：简要数据

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Adaptive homeostasis enables rapid cellular signaling, leading to transcriptional and translational modifications (Davies, 2016) [1]. The Proteasome is one of the main cellular proteolytic enzymes that plays an essential role in the rapid clearance of oxidatively damaged cellular proteins, and is highly responsive to oxidative stress. Upon exposure to even very low, signaling levels of oxidants, the predominant form of the Proteasome becomes the ATP-independent 20S proteasome that enables rapid clearance of damaged proteins. Subsequently there is also a concurrent upregulation of de novo 20S proteasome synthesis. These cellular adaptations not only ensure effective and efficient removal of damaged proteins, but prepare cells to better cope with future, more severe oxidative insults. Male and female Drosophila melanogaster fruit flies were pretreated with an adaptive amount of an oxidant (10 µM hydrogen peroxide or 0.5 µM paraquat) to assess the changes in proteolytic capacity and the role of the 20S proteasome. Additionally, the adaptive signaling by non-damaging amounts of hydrogen peroxide or paraquat) were used to assess changes in male and female fruit flies, following a subsequent more toxic amount of the two oxidants. Further analysis and detailed results about the adaptive role of the 20S proteasome in multiple D. melanogaster strains can be found in “Sexual Dimorphism in Oxidant-Induced Adaptive Homeostasis in Multiple Wild-Type D. melanogaster Strains” (Pomatto et al., 2018) .
机译：自适应稳态使细胞快速信号传导，导致转录和翻译修饰（Davies，2016）[1]。蛋白酶体是主要的细胞蛋白水解酶之一，在快速清除氧化损伤的细胞蛋白中起着至关重要的作用，并且对氧化应激反应高度敏感。暴露于甚至非常低的信号传导水平的氧化剂后，蛋白酶体的主要形式变为独立于ATP的20S蛋白酶体，能够快速清除受损的蛋白质。随后，从头20S蛋白酶体合成也同时上调。这些细胞适应性不仅可以确保有效，有效地去除受损的蛋白质，还可以使细胞做好准备，以更好地应对未来更严重的氧化损伤。用适量的氧化剂（10μm过氧化氢或0.5μm百草枯）预处理果蝇的果蝇，以评估蛋白水解能力的变化和20S蛋白酶体的作用。另外，在随后的两种氧化剂的毒性更高之后，通过无损伤的过氧化氢或百草枯的适应性信号转导来评估雄性和雌性果蝇的变化。有关20S蛋白酶体在多种D. melanogaster菌株中的适应性作用的进一步分析和详细结果，可参见``在多种野生型D. melanogaster菌株中由氧化剂引起的自适应稳态中的性二态性''（Pomatto等人，2018） 。

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