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首页> 美国卫生研究院文献>Current Developments in Nutrition >Vitamin A and Retinoic Acid Combined Have a More Potent Effect Compared with Vitamin A Alone on the Uptake of Retinol into Extrahepatic Tissues of Neonatal Rats Raised under Vitamin A–Marginal Conditions
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Vitamin A and Retinoic Acid Combined Have a More Potent Effect Compared with Vitamin A Alone on the Uptake of Retinol into Extrahepatic Tissues of Neonatal Rats Raised under Vitamin A–Marginal Conditions

机译：维生素A和视黄酸联合使用比单独使用维生素A对在维生素A边缘条件下饲养的新生大鼠肝外组织中吸收视黄醇的作用更强

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>Background: Vitamin A (VA; retinol) supplementation is widely used to reduce child mortality in low-income countries. However, existing research suggests that supplementation with VA alone may not be optimal for infants. >Objective: We compared the effect of VA with VA combined with retinoic acid (VARA) on retinol uptake and turnover in organs of neonatal rats raised under VA-marginal conditions. >Methods: Secondary analysis was conducted on data obtained from 2 previous kinetic studies in Sprague-Dawley neonatal rats nursed by dams fed a VA-marginal diet (0.35 mg retinol equivalents/kg diet). On postnatal day 4, pups had been treated with a single dose of VA (6 μg/g; n = 52; VA study), VA + 10% retinoic acid (6 μg/g; n = 42; VARA study), or placebo (canola oil; n = 94; both studies), all of which contained ∼2 μCi [3H]retinol as the tracer for VA. Total retinol and tracer concentrations were measured in plasma and tissues from 1 h to 14 d after dosing. Control group data from both studies were merged before analysis. Kinetic parameters were re-estimated and compared statistically. >Results: VARA supplementation administered to neonatal rats within a few days after birth resulted in a lower turnover of retinol in the lungs, kidneys, and carcass and less frequent recycling of retinol between plasma and organs (100 compared with 288 times in the VARA- compared with the VA-treated group). Although VA supplementation resulted in a higher concentration of retinol in the liver, VARA supplementation led to a higher uptake of postprandial retinyl esters into the lungs, intestines, and carcass. >Conclusion: Given the relatively higher retinol uptake into several extrahepatic organs of neonates dosed orally with VARA, this form of supplementation may serve as a targeted treatment of low VA concentrations in extrahepatic organs that continue to develop postnatally.
机译：>背景：在低收入国家，补充维生素A（VA;视黄醇）被广泛用于降低儿童死亡率。但是，现有研究表明，单独添加VA对婴儿可能不是最佳选择。 >目的：我们比较了VA和VA联合视黄酸（VARA）对在VA边缘条件下饲养的新生大鼠器官中视黄醇摄取和更新的影响。 >方法：对先前两次研究的数据进行了二次分析，这些数据是在Sprague-Dawley新生大鼠中进行的，这些新生大鼠由大坝喂养的VA边缘饮食（0.35 mg视黄醇当量/ kg饮食）喂养。在出生后的第4天，对幼犬进行单剂量VA（6μg/ g； n = 52； VA研究），VA + 10％视黄酸（6μg/ g； n = 42; VARA研究）或安慰剂（低芥酸菜子油； n = 94；两项研究），所有这些均含〜2μCi[ 3 H]视黄醇作为VA示踪剂。给药后1 h至14 d测量血浆和组织中总的视黄醇和示踪剂浓度。两项研究的对照组数据在分析之前合并。重新估计动力学参数，并进行统计学比较。 >结果：新生大鼠在出生后几天内补充VARA，导致其在肺，肾和，体中视黄醇的转换率降低，血浆和器官之间视黄醇的回收利用频率降低（100倍于与VA治疗组相比，VARA-的治疗次数为288倍）。尽管VA补充会导致肝脏中视黄醇的浓度更高，但VARA补充会导致餐后视黄酯进入肺，肠和higher体的摄入量增加。 >结论：鉴于口服VARA的新生儿对数个肝外器官的视黄醇摄取量相对较高，这种补充形式可作为针对出生后持续发展的肝外器官中低VA浓度的靶向治疗。

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