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首页> 美国卫生研究院文献>Critical Care Research and Practice >Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients
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Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients

机译：系统性和尿中性粒细胞明胶酶相关的脂蛋白是未选的重症患者急性肾脏损伤的较差预测指标。

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Background. Neutrophil gelatinase-associated lipocalin (NGAL) in serum and urine have been suggested as potential early predictive biological markers of acute kidney injury (AKI) in selected critically ill patients. Methods. We performed a secondary analysis of a multicenter prospective observational cohort study of unselected critically ill patients. Results. The analysis included 140 patients, including 57 patients who did not develop AKI, 31 patients who developed AKI, and 52 patients with AKI on admission to the ICU. Levels of sNGAL and uNGAL on non-AKI days were significantly lower compared to levels of sNGAL on RIFLERISK days, RIFLEINJURY days, and RIFLEFAILURE days. The AUC of sNGAL for predicting AKI was low: 0.45 (95% confidence interval (CI) 0.27–0.63) and 0.53 (CI 0.38–0.67), 2 days and 1 day before development of AKI, respectively. The AUC of uNGAL for predicting AKI was also low: 0.48 (CI 0.33–0.62) and 0.48 (CI 0.33–0.62), 2 days and 1 day before development of AKI, respectively. AUC of sNGAL and uNGAL for the prediction of renal replacement therapy requirement was 0.47 (CI 0.37–0.58) and 0.26 (CI 0.03–0.50). Conclusions. In unselected critically ill patients, sNGAL and uNGAL are poor predictors of AKI or RRT.
机译：背景。血清和尿液中性粒细胞明胶酶相关的脂蛋白（NGAL）已被建议作为某些危重病人急性肾损伤（AKI）的潜在早期预测生物学标记。方法。我们对未选择的危重患者进行了多中心前瞻性观察队列研究的二级分析。结果。该分析包括140例患者，其中包括57例未发展为AKI的患者，31例发展为AKI的患者和52例入住ICU的AKI患者。与RIFLERISK日，RIFLEINJURY日和RIFLEFAILURE日的sNGAL相比，非AKI日的sNGAL和uNGAL的水平显着降低。预测AKI的sNGAL的AUC较低：分别在AKI发生前2天和1天分别为0.45（95％置信区间（CI）0.27-0.63）和0.53（CI 0.38-0.67）。用于预测AKI的uNGAL的AUC也很低：分别在AKI发生前2天和1天分别为0.48（CI 0.33-0.62）和0.48（CI 0.33-0.62）。 sNGAL和uNGAL的AUC预测肾脏替代治疗的需要量分别为0.47（CI 0.37-0.58）和0.26（CI 0.03-0.50）。结论。在未选的重症患者中，sNGAL和uNGAL是AKI或RRT的不良预测指标。

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