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首页> 美国卫生研究院文献>The Journal of Veterinary Medical Science >Evaluation of quality of anesthesia and analgesia and of vital signs afterintramuscular administration of a combination of butorphanol medetomidine and alfaxalonein cats
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Evaluation of quality of anesthesia and analgesia and of vital signs afterintramuscular administration of a combination of butorphanol medetomidine and alfaxalonein cats

机译：麻醉和镇痛质量以及术后生命体征的评估肌注布托啡诺美托咪定和阿法沙酮的组合在猫

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This study evaluated the quality of anesthesia, duration of analgesia and changes in vital signs after intramuscular administration of a combination of butorphanol, medetomidine and alfaxalone in domestic cats. Ten healthy adult domestic cats (weighing 2.9 ± 0.5 kg) were used in this study. Rectal temperature (T), pulse rate (PR), respiratory rate (fR) and systolic arterial pressure (SAP) were measured and recorded prior to intramuscular (IM) administration of butorphanol (0.2 mg/kg), medetomidine (20 ug/kg) and alfaxalone (5 mg/kg) and then every 10 min until return of consciousness. Qualitative scores for induction of anesthesia and recovery were allocated, duration of anesthesia and recovery were calculated, and adverse events were recorded. A needle prick with a 22-gauge hypodermic needle was used to assess analgesia. Scores for induction and recovery quality were acceptable. No significant adverse events except nausea (7/10) and vomiting (5/10) were observed. The mean ± SD times from induction to extubation and to standing (full recovery) were 114 ± 8 and 125 ± 7 min, respectively. There were statistically significant changes in PR, fR and SAP after induction of anesthesia. The combination of butorphanol, medetomidine and alfaxalone provided acceptable quality of anesthesia and analgesia and exerted minimal cardiopulmonary effects in domestic cats.
机译：这项研究评估了在家猫中肌肉注射布托啡诺，美托咪定和阿法沙酮的组合后的麻醉质量，镇痛时间和生命体征的变化。这项研究使用了十只健康的成年家猫（体重2.9±0.5千克）。在肌内（IM）施用丁苯啡诺（0.2 mg / kg），美托咪定（20 ug / kg）之前，测量并记录直肠温度（T），脉搏率（PR），呼吸频率（fR）和收缩压（SAP）。 ）和阿法沙酮（5 mg / kg），然后每10分钟直到意识恢复。分配麻醉诱导和恢复的定性评分，计算麻醉和恢复的持续时间，并记录不良事件。用22号皮下注射针头刺针来评估镇痛效果。诱导和恢复质量得分是可以接受的。除恶心（7/10）和呕吐（5/10）外，没有观察到明显的不良事件。从诱导到拔管和站立（完全恢复）的平均±SD时间分别为114±8和125±7 min。麻醉诱导后PR，fR和SAP的变化有统计学意义。布托啡诺，美托咪定和阿法沙酮的组合可提供可接受的麻醉和镇痛效果，并且对家猫的心肺功能影响最小。

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