首页> 美国卫生研究院文献>The Journal of Veterinary Medical Science >The precursor osteoblast-like cell MC3T3-E1 cell line enhancessodium–calcium exchanger 1 (Ncx1) gene expression by stretch stimuliprior to osteoblast differentiation

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The precursor osteoblast-like cell MC3T3-E1 cell line enhancessodium–calcium exchanger 1 (Ncx1) gene expression by stretch stimuliprior to osteoblast differentiation

机译：前体成骨样细胞MC3T3-E1细胞系增强钠钙交换蛋白1（Ncx1）基因表达的拉伸刺激成骨细胞分化之前

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This study evaluated the expression of genes involved in the concentration of Ca²⁺ in precursor osteoblast-like cell, MC3T3-E1 subjected to stretching stimuli. Transient receptor potential vanilloid 4 (Trpv4) gene expression, the factor that is activated by stretch stimulation and enables inflow of Ca²⁺ from the extracellular space, was not affected as a result of stretch stimulation; conversely, the expression of sodium-calcium exchanger 1 (Ncx1) gene involved in outflow of intracellular Ca²⁺ increased, depending on stimulation intensity. Localization of Ca²⁺ correlated with the positioning of the endoplasmic reticulum, and intracellular Ca²⁺ decreased in inverse proportion to the intensity of the stretching force. These results suggest that stretch stimulation activates intracellular Ca²⁺ elimination rather than Ca²⁺ uptake before osteoblast differentiation.

机译：本研究评估了受拉伸刺激的前体成骨样细胞MC3T3-E1中Ca ^{2 + 浓度相关基因的表达。瞬时刺激电位香草酸4（Trpv4）基因表达是受拉伸刺激激活的因子，该因子可通过拉伸刺激激活并能使Ca ^{2 + 从细胞外空间流入；相反，取决于刺激强度，参与细胞内Ca ^{2 + 流出的钠钙交换蛋白1（Ncx1）基因的表达增加。 Ca ^{2 + 的定位与内质网的位置有关，细胞内Ca ^{2 + 的减小与拉伸力的强度成反比。这些结果表明，拉伸刺激在成骨细胞分化之前激活细胞内Ca ^{2 + 的消除，而不是Ca ^{2 + 的吸收。}}}}}}}

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期刊名称 The Journal of Veterinary Medical Science
作者
Katsuhiko WARITA; Ryo AOKI; Naoki KITAMURA; Izumi SHIBUYA; Yoshinao Z. HOSAKA;
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作者单位

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年(卷),期 2019(81),4
年度 2019
页码 508–512
总页数 5
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
Ncx1 Ncx3 osteoblast differentiation stretch stimulus Trpv4;

机译：Ncx1;Ncx3;成骨细胞分化;伸展刺激;Trpv4;

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专利

1. The precursor osteoblast-like cell, MC3T3-E1 cell line, enhances sodium–calcium exchanger 1 (Ncx1) gene expression by stretch stimuli prior to osteoblast differentiation [J] . Katsuhiko WARITA, Ryo AOKI, Naoki KITAMURA, The Journal of Veterinary Medical Science . 2019,第4期

机译：前成骨细胞样细胞MC3T3-E1细胞系通过成骨细胞分化前的拉伸刺激增强钠钙交换器1（Ncx1）基因表达
2. Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells. [J] . Takeuchi T, Tsuboi T, Arai M, Biochemical Pharmacology . 2001,第5期

机译：破骨细胞分化因子在MC3T3-E1成骨细胞样细胞中的表达介导的肾上腺能刺激破骨细胞生成。
3. Independent and cooperative roles of tumor necrosis factor-alpha, nuclear factor-kappaB, and bone morphogenetic protein-2 in regulation of metastasis and osteomimicry of prostate cancer cells and differentiation and mineralization of MC3T3-E1 osteoblast-like cells. [J] . Graham TR, Agrawal KC, Abdel Mageed AB Cancer science. . 2010,第1期

机译：肿瘤坏死因子-α，核因子-κB和骨形态发生蛋白2在调节前列腺癌细胞的转移和成骨作用以及MC3T3-E1成骨细胞样细胞的分化和矿化中的独立和协同作用。
4. Gene Expression Profile of Osteoblast-Like Cells on Calcium Phosphate Biomaterials [C] . Taro Takemura, Hongsong Fan, Toshiyuki lkoma, Bioceramics . 2007

机译：磷酸钙生物材料上成骨细胞样细胞的基因表达谱
5. Dairy-derived bioactive alpha-linolenic acid, conjugated linoleic acid, and calcium as modulators of ST2 stromal, MC3T3-L1 adipocyte-like, and MC3T3-E1 osteoblast-like cell metabolism. [D] . Kim, Youjin. 2011

机译：乳制品衍生的生物活性α-亚麻酸，共轭亚油酸和钙，可调节ST2基质，MC3T3-L1脂肪细胞样和MC3T3-E1成骨细胞样细胞代谢。
6. Independent and cooperative roles of tumor necrosis factor-α nuclear factor-κB and bone morphogenetic protein-2 in regulation of metastasis and osteomimicry of prostate cancer cells and differentiation and mineralization of MC3T3-E1 osteoblast-like cells [O] . Tisheeka R. Graham, Krishna C. Agrawal, Asim B. Abdel-Mageed -1

机译：在转移和前列腺癌细胞和mC3T3-E1的分化和矿化成骨细胞样细胞的osteomimicry调节肿瘤坏死因子α核因子-κB和骨形态发生蛋白2的独立和协同作用
7. The precursor osteoblast-like cell, MC3T3-E1 cell line, enhances sodium–calcium exchanger 1 (Ncx1) gene expression by stretch stimuli prior to osteoblast differentiation [O] . Katsuhiko WARITA, Ryo AOKI, Naoki KITAMURA, 2019

机译：前体成骨细胞样MC3T3-E1细胞系，通过在成骨细胞分化之前通过拉伸刺激增强钠钙交换剂1（ Ncx1 ）基因表达

The precursor osteoblast-like cell MC3T3-E1 cell line enhancessodium–calcium exchanger 1 (Ncx1) gene expression by stretch stimuliprior to osteoblast differentiation

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