• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Clinical Ophthalmology (Auckland N.Z.) >The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal
【2h】

The short-term physiological impact of switching reusable silicone hydrogel wearers into a hydrogel daily disposable multifocal

机译：将可重复使用的有机硅水凝胶佩戴者转换为水凝胶日用一次性多焦点眼镜的短期生理影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

>Purpose: To evaluate ocular physiological responses to etafilcon A multifocal (etMF) daily disposable (DD) lenses after 4 weeks of wear, when switching from habitual silicone hydrogel (SiHy) daily wear.>Method: A single-arm, open-label, bilateral dispensing study was conducted in 39 habitual spherical SiHy wearers (14 hyperopes; 25 myopes). Clinical visits occurred with habitual SiHy (control) at baseline and after 4 weeks of etMF DD open-eye lens wear at exit. Objective limbal/bulbar hyperemia using the Oculus K5M (0–4) and subjective grading of lid wiper epitheliopathy (LWE) (0–4) were tested for non-inferiority (NI), using a margin of 1 grade. Corneal thickness along a 10 mm cord was measured using the Visante OCT and tested for NI using a 30 μm margin. Corneal staining area was graded (0–100%).>Results: The least-square mean differences (LSMD) and 95% confidence interval (95% CI) between etMF DD and habitual SiHy in central and peripheral corneal thickness (μm) were 3.64 (−2.0, 9.29) and 3.0 (−7.72, 13.72) in hyperopic, and 3.56 (−0.66, 7.78) and 6.40 (−1.62, 14.42) in myopic subjects. The LSMD (95% CI) for bulbar and limbal hyperemia were −0.08 (−0.19, 0.02) and −0.01 (−0.12, 0.09) in hyperopes, and 0.04 (−0.03, 0.12) and 0.04 (−0.04, 0.11) in myopes. The LSMD (95% CI) for LWE were 0.11 (−0.39, 0.60) and 0.30 (−0.07, 0.67) for hyperopes and myopes, respectively.>Conclusions: No clinically significant differences in a variety of physiological responses were found when habitual reusable SiHy daily wear subjects were refitted into hydrogel etMF, when the subjects were followed for 4 weeks.
机译：>目的：：从佩戴习惯的硅水凝胶（SiHy）改为每天佩戴4周后，评估对etafilcon A多焦点（etMF）每日免洗（DD）镜片的眼部生理反应。>方法： 在39位习惯性球形SiHy佩戴者（14例远视； 25例近视）中进行了单臂，开放标签，双边分配研究。在基线时以及出院时佩戴etMF DD睁眼晶状体4周后，习惯性SiHy（对照）发生临床访视。使用Oculus K5M（0–4）进行客观性角膜缘/鳞茎充血和睑板刮水上皮病（LWE）（0–4）的主观评分，以1级为标准测试非劣性（NI）。使用Visante OCT测量沿10毫米软线的角膜厚度，并使用30μm裕度测试NI。角膜染色区域分级为（0-100％）。>结果： etMF DD与习惯性SiHy在中枢和外周的最小二乘均方差（LSMD）和95％置信区间（95％CI）远视患者的角膜厚度（μm）为3.64（−2.0，9.29）和3.0（−7.72，13.72），近视患者为3.56（−0.66，7.78）和6.40（−1.62，14.42）。球囊和角膜缘充血的LSMD（95％CI）在远视眼中为-0.08（-0.19，0.02）和-0.01（-0.12，0.09），在0.04（-0.03，0.12）和0.04（-0.04，0.11）近视。 LWE的LSMD（95％CI）分别为远视和近视的0.11（−0.39，0.60）和0.30（−0.07，0.67）。>结论：在各种生理学上均无临床显着差异当将习惯性可重复使用的SiHy日常穿着受试者重新安装到水凝胶etMF中时，发现了这种反应，当受试者随访4周时。

著录项

相似文献

  • 外文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号