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首页> 美国卫生研究院文献>Clinical Pediatric Endocrinology >A Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy SuccessfullyManaged with Subcutaneous Octreotide Injection and Nocturnal Intravenous GlucoseSupply
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A Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy SuccessfullyManaged with Subcutaneous Octreotide Injection and Nocturnal Intravenous GlucoseSupply

机译：婴儿持续性高胰岛素低血糖症一例成功皮下注射奥曲肽和夜间静脉注射葡萄糖治疗供应

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摘要

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is often resistant to medical therapy and is normally treated by subtotal pancreatectomy to avoid neurological complications. However, many problems after surgery, such as recurrence of hypoglycemia and diabetes mellitus, remain to be solved. This report concerns a case of PHHI that was resistant to octreotide or diazoxide alone but was successfully controlled with subcutaneous injection of octreotide in combination with nocturnal glucose infusion through central venous catheter. The patient exhibited natural remission of hyperinsulinism with age, and all treatment was ceased at the age of 4 yr. Growth and neurological development of the patient have been normal. This combined therapy can be a therapeutic option as a substitute for surgical solutions.
机译：婴儿持续性高胰岛素血症性低血糖症（PHHI）通常对药物治疗有抵抗力，并且通常应行全切胰腺切除术来避免神经系统并发症。然而，手术后的许多问题，例如低血糖症的复发和糖尿病，仍有待解决。该报告涉及一例仅对奥曲肽或二氮嗪具有抗药性但通过皮下注射奥曲肽与通过中央静脉导管夜间注入葡萄糖相结合成功控制的PHHI病例。随着年龄的增长，患者表现出高胰岛素血症的自然缓解，并且所有治疗均在4岁时停止。患者的生长和神经发育正常。这种联合疗法可以作为替代手术解决方案的治疗选择。

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