首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea-pigs. III. The role of adjuvants in the induction of disease.

【2h】

Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea-pigs. III. The role of adjuvants in the induction of disease.

机译：实验性自身免疫性肾小管间质性疾病在豚鼠中的发病机理研究。三佐剂在诱发疾病中的作用。

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Experimental renal tubulointerstitial disease is induced in guinea-pigs by anti-tubular basement membrane autoantibodies. The complete mechanism of mononuclear cell accumulation in the target organ is not known; however, in addition to antibody, complement and radiosensitive leucocytes are important. In the present experiments we explored the influence of adjuvant in the accumulation of mononuclear cells in kidneys of actively or passively immunized guinea-pigs. We found that renal disease could be induced without adjuvant, by multiple injections of rabbit tubular basement membrane. Lesions were comparable to those groups which received a single dose of antigen in Freund's complete or pertussis vaccine adjuvant. Passive transfer of nephritis confirmed that adjuvant is not necessary for either the accumulation of mononuclear cells or the formation of antibodies with particularly potent pathogenicity.

机译：抗肾小管基底膜自身抗体在豚鼠中诱发实验性肾小管间质疾病。靶器官中单核细胞积累的完整机制尚不清楚；然而，除了抗体之外，补体和放射敏感性白细胞也很重要。在本实验中，我们探索了佐剂对主动或被动免疫豚鼠肾脏中单核细胞积累的影响。我们发现，多次注射兔肾小管基底膜可在没有佐剂的情况下诱发肾脏疾病。病变与那些在弗氏完全或百日咳疫苗佐剂中接受单剂量抗原的组相当。肾炎的被动转移证实，佐剂对于单核细胞的积累或具有特别强的致病性的抗体的形成不是必需的。

著录项

期刊名称 Clinical and Experimental Immunology
作者
U H Rudofsky;
展开▼
作者单位

展开▼
年(卷),期 1976(25),3
年度 1976
页码 455–461
总页数 7
原文格式 PDF
正文语种
中图分类免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Experimental Autoimmune Renal Cortical Tubulointerstitial Disease in Guinea Pigs Lacking the Fourth Component of Complement (C4) [J] . Bernard Pollara, Philip R. B. McMaster, Raymond W. Steblay, The journal of immunology . 1974,第4期

机译：缺乏补体第四成分（C4）的豚鼠实验性自身免疫性肾皮质肾小管间质疾病
2. The role of cytokine mRNA stability in the pathogenesis of autoimmune disease. [J] . Seko Y, Cole S, Kasprzak W, Autoimmunity reviews . 2006,第5期

机译：细胞因子mRNA稳定性在自身免疫性疾病发病机理中的作用。
3. Role of Fas--FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease. [J] . Sabelko Downes-KA, Russell JH, Cross AH Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1999,第1a2期

机译：Fas-FasL相互作用在自身免疫性脱髓鞘疾病的发病机理和调节中的作用。
4. H, Water and Urea Transport in the Inner Medullary Collecting Duct and Their Role in the Prevention and Pathogenesis of Renal Stone Disease [C] . Susan M. Wall, Janet D. Klein International Urolithiasis Research Symposium . 2008

机译：h，水和尿素运输在内髓内收集管道及其在肾石疾病预防和发病机制中的作用
5. The centrosome: Identification of new components, a study of behaviour, and its role in human autoimmune disease. [D] . Mack, Gary James. 1999

机译：中心体：新成分的鉴定，行为及其在人类自身免疫性疾病中的作用的研究。
6. Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea-pigs. IV. failure to inhibit mononuclear cell accumulation with niridazole. [O] . U H Rudofsky, B Pollara 1977

机译：实验性自身免疫性肾小管间质性疾病在豚鼠中的发病机理研究。 IV。用尼立达唑不能抑制单核细胞积累。
7. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease. [O] . Gold, R, Giegerich, G, Hartung, H P, 1995

机译：Lewis大鼠实验性自身免疫性脑脊髓炎中T细胞受体（TCR）的使用：TCRβ链可变区Vβ8.2阳性T细胞对于疾病的诱导和病程并不是必需的。
8. Role of Respirable Saudi Arabian Sand and Pyridostigmine in the Gulf War syndrome: An Autoimmune Adjuvant Disease. [R] . Sopori, M. L. 2002

机译：可吸入沙特阿拉伯沙和吡啶斯的明在海湾战争综合症中的作用：自身免疫佐剂病。

Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea-pigs. III. The role of adjuvants in the induction of disease.

摘要

著录项

相似文献

相关主题

期刊订阅