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Effect of human colostrum and infant formula on the phagocytic activity of macrophages. I. Resident and stimulated mouse peritoneal macrophages.

机译:人初乳和婴儿配方奶粉对巨噬细胞吞噬活性的影响。 I.常驻和受刺激的小鼠腹膜巨噬细胞。

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摘要

Phagocytosis and degradation of radiolabelled human transferrin-anti-transferrin immune complexes by resident and stimulated mouse peritoneal macrophages was inhibited by liquid infant formula, particularly in the case of resident cells. Mouse peritoneal macrophages exposed to infant formula were shown by immunofluorescence to bind casein and beta-lactoglobulin, but there was little binding of alpha-lactalbumin. Comparison of various artificial milks, cow's milk and purified casein indicated that both the concentration and the degree of denaturation of casein may be important in the impairment of macrophage function by milk. It is suggested that bottle feeding of infants might result in impairment of macrophage function in the small intestine.
机译:液态婴儿配方奶粉抑制了常驻和刺激的小鼠腹膜巨噬细胞对放射性标记的人转铁蛋白-抗转铁蛋白免疫复合物的吞噬作用和降解,特别是在常驻细胞的情况下。免疫荧光显示暴露于婴儿配方食品的小鼠腹膜巨噬细胞结合酪蛋白和β-乳球蛋白,但几乎不结合α-乳白蛋白。各种人造乳,牛乳和纯化的酪蛋白的比较表明,酪蛋白的浓度和变性程度可能在牛奶损害巨噬细胞功能中很重要。建议婴儿奶瓶喂养可能会导致小肠巨噬细胞功能受损。

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