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首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1.
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Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1.

机译：中毒性休克综合征患者血清IgG亚类模式失衡：中毒性休克综合征毒素1的特异性IgG1和IgG4亚类抗体缺乏。

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An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-specificity of antibodies to toxic shock syndrome toxin (TSST-1) was investigated by a solid-phase radioimmunoassay. TSS-patients lacked pre-immunity to TSST-1 in all four IgG subclasses. Normally acquired immunity to the toxin as well as the serological response developing in two patients with TSS was generally restricted to IgG1 and IgG4. A strong booster response of all four IgG subclasses was seen in three patients with S. aureus septicaemia due to TSST-1 producing strains. The lack of specific IgG1 and IgG4 antibodies to TSST-1 and the low serum IgG subclass levels found in the TSS-patients could be of pathogenetic significance and help to explain the susceptibility to TSS in certain individuals.
机译：在10例中毒性休克综合征（TSS）患者中鉴定出血清IgG亚类模式失衡，显示各种组合的亚类水平非常低。与正常对照相比，IgG2水平显着降低。通过固相放射免疫分析法研究了中毒性休克综合征毒素（TSST-1）抗体的IgG亚类特异性。 TSS患者在所有四个IgG亚类中均缺乏针对TSST-1的免疫前。正常情况下，两名TSS患者对毒素的正常免疫以及血清学反应通常仅限于IgG1和IgG4。在三例由于产生TSST-1的菌株引起的金黄色葡萄球菌败血症患者中，所有四个IgG亚类均出现了强烈的加强应答。在TSS患者中缺乏针对TSST-1的特异性IgG1和IgG4抗体的缺乏以及血清IgG亚类水平低可能具有致病性，并有助于解释某些人对TSS的易感性。

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