• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Pharmacy: Journal of Pharmacy Education and Practice >Outcomes When Using Adjunct Dexmedetomidine with Propofol Sedation in Mechanically Ventilated Surgical Intensive Care Patients
【2h】

Outcomes When Using Adjunct Dexmedetomidine with Propofol Sedation in Mechanically Ventilated Surgical Intensive Care Patients

机译：机械通气手术重症监护患者使用辅助右美托咪定联合丙泊酚镇静的结果

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

>Objective: Compare the duration of mechanical ventilation between patients receiving sedation with continuous infusions of propofol alone or combination with the use of dexmedetomidine and propofol. >Design: Retrospective, propensity matched (1:1) cohort study, employing eight variables chosen a priori for matching. Timing of exposure to dexmedetomidine initiation was incorporated into a matching algorithm. >Setting: Level 1, university-based, 32-bed, adult, mixed trauma and surgical intensive care unit (SICU). Continuous sedation was delivered according to a protocol methodology with daily sedation vacation and spontaneous breathing trials. Choice of sedation agent was physician directed. >Patients: Between 2010 and 2014, 149 SICU patients receiving mechanical ventilation for >24 h received dexmedetomidine with propofol. Propensity matching resulted in 143 pair cohorts. >Interventions: Dexmedetomidine with propofol or propofol alone. >Measurements and Main Results: There was no statistical difference in SICU length of stay (LOS), with a median absolute difference of 5.3 h for propofol alone group (p = 0.43). The SICU mortality was not statistically different (RR = 1.002, p = 0.88). Examining a 14-day period post-treatment with dexmedetomidine, on any given day (excluding days 1 and 14), dexmedetomidine with propofol-treated patients had a 0.5% to 22.5% greater likelihood of being delirious (CAM-ICU positive). In addition, dexmedetomidine with propofol-treated patients had a 4.5% to 18.8% higher likelihood of being above the target sedation score (more agitated) compared to propofol-alone patients. >Conclusions: In this propensity matched cohort study, adjunct use of dexmedetomidine to propofol did not show a statistically significant reduction with respect to mechanical ventilation (MV) duration, SICU LOS, or SICU mortality, despite a trend toward receiving fewer hours of propofol. There was no evidence that dexmedetomidine with propofol improved sedation scores or reduced delirium.
机译：>目的：比较接受镇静的患者与单独连续输注异丙酚或联合使用右美托咪定和丙泊酚的镇静患者的机械通气时间。 >设计：回顾性，倾向匹配（1：1）队列研究，采用了先验选择的八个变量进行匹配。暴露于右美托咪定开始的时间被纳入匹配算法。 >设置：：第1级，基于大学，32张床，成人，混合创伤和外科重症监护室（SICU）。根据协议方法进行连续镇静，包括每天的镇静休假和自发呼吸试验。镇静剂的选择由医生指导。 >患者：在2010年至2014年间，接受机械通气> 24小时的149名SICU患者接受了右美托咪定和丙泊酚的治疗。倾向匹配导致143对队列。 >干预：右美托咪定与丙泊酚或丙泊酚单独使用。 >测量和主要结果： SICU住院天数（LOS）没有统计学差异，仅丙泊酚组的中位绝对差为5.3 h（p = 0.43）。 SICU死亡率无统计学差异（RR = 1.002，p = 0.88）。在任何给定的一天（不包括第1天和第14天）检查右美托咪定治疗后的14天期间，右美托咪定与丙泊酚治疗的患者出现妄想的可能性增加0.5％至22.5％（CAM-ICU阳性）。此外，与单独使用异丙酚的患者相比，右美托咪定联合丙泊酚治疗的患者高于目标镇静评分（更激动）的可能性高4.5％至18.8％。 >结论：在这项倾向匹配的队列研究中，右美托咪定与丙泊酚的辅助使用并未显示出机械通气（MV）持续时间，SICU LOS或SICU死亡率有统计学上的显着降低，尽管趋势接受较少的丙泊酚小时。没有证据表明右美托咪定联合丙泊酚可改善镇静评分或减少del妄。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号