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首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögrens syndrome: clinical implications and effects of B cell-targeted therapies
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Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögrens syndrome: clinical implications and effects of B cell-targeted therapies

机译：疾病中B细胞亚群的转化性微型综述系列。系统性红斑狼疮和干燥综合征中的过渡性B细胞：B细胞靶向疗法的临床意义和影响

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OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON B CELL SUBSETS IN DISEASEB cells in multiple sclerosis: drivers of disease pathogenesis and Trojan horse for Epstein—Barr virus entry to the central nervous system? Clinical and Experimental Immunology 2012, 167: 1–6. Reconstitution after haematopoietic stem cell transplantation – revelation of B cell developmental pathways and lineage phenotypes. Clinical and Experimental Immunology 2012, 167: 15–25.Systemic lupus erythematosus (SLE) and Sjögren's syndrome are autoimmune disorders which are characterized by a disturbed B cell homeostasis which leads ultimately to dysfunction of various organs. One of the B cell subsets that appear in abnormal numbers is the population of transitional B cells, which is increased in the blood of patients with SLE and Sjögren's syndrome. Transitional B cells are newly formed B cells. In mice, transitional B cells undergo selection checks for unwanted specificity in the bone marrow and the spleen in order to eliminate autoreactive B cells from the circulating naive B cell population. In humans, the exact anatomical compartments and mechanisms of the specificity check-points for transitional B cells remain unclear, but appear to be defective in SLE and Sjögren's syndrome. This review aims to highlight the current understanding of transitional B cells and their defects in the two disorders before and after B cell-targeted therapies.
机译：该小型复习系列中的其他文章发表于多发性硬化症中DISEASEB细胞的B细胞亚群：疾病发病机制的驱动者和爱泼斯坦的特洛伊木马-巴尔病毒进入中枢神经系统？临床与实验免疫学2012，167：1-6。造血干细胞移植后的重建– B细胞发育途径和谱系表型的启示。临床与实验免疫学2012，167：15–25。系统性红斑狼疮（SLE）和Sjögren综合征是自身免疫疾病，其特征是B细胞稳态失调，最终导致各种器官功能障碍。数量异常的B细胞亚群之一是过渡性B细胞的数量，在SLE和Sjögren综合征患者的血液中B细胞的数量增加。过渡性B细胞是新形成的B细胞。在小鼠中，对过渡性B细胞进行选择检查，以检查骨髓和脾脏中是否具有不需要的特异性，以便从循环中的原始B细胞群中消除自身反应性B细胞。在人类中，尚不清楚过渡性B细胞的确切解剖部位和特异性检查点的机制，但似乎在SLE和Sjögren综合征中存在缺陷。这篇综述旨在强调目前对B细胞靶向治疗前后两种疾病中过渡性B细胞及其缺陷的认识。

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