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首页> 美国卫生研究院文献>Pharmacy: Journal of Pharmacy Education and Practice >Women’s Beliefs on Early Adherence to Adjuvant Endocrine Therapy for Breast Cancer: A Theory-Based Qualitative Study to Guide the Development of Community Pharmacist Interventions
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Women’s Beliefs on Early Adherence to Adjuvant Endocrine Therapy for Breast Cancer: A Theory-Based Qualitative Study to Guide the Development of Community Pharmacist Interventions

机译：妇女对乳腺癌的辅助内分泌治疗的早期坚持的信念：基于理论的定性研究指导社区药剂师干预的发展

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Adjuvant endocrine therapy (AET) taken for a minimum of five years reduces the recurrence and mortality risks among women with hormone-sensitive breast cancer. However, adherence to AET is suboptimal. To guide the development of theory-based interventions to enhance AET adherence, we conducted a study to explore beliefs regarding early adherence to AET. This qualitative study was guided by the Theory of Planned Behavior (TPB). We conducted focus groups and individual interviews among women prescribed AET in the last two years (n = 43). The topic guide explored attitudinal (perceived advantages and disadvantages), normative (perception of approval or disapproval), and control beliefs (barriers and facilitating factors) towards adhering to AET. Thematic analysis was conducted. Most women had a positive attitude towards AET regardless of their medication-taking behavior. The principal perceived advantage was protection against a recurrence while the principal inconvenience was side effects. Almost everyone approved of the woman taking her medication. The women mentioned facilitating factors to encourage medication-taking behaviors and cope with side effects. For adherent women, having trouble establishing a routine was their main barrier to taking medication. For non-adherent women, it was side effects affecting their quality of life. These findings could inform the development of community pharmacy-based adherence interventions.
机译：进行至少五年的辅助内分泌治疗（AET）可以降低激素敏感性乳腺癌女性的复发和死亡风险。但是，遵守AET是次优的。为了指导基于理论的干预措施的发展以增强AET的依从性，我们进行了一项研究以探索有关早期遵守AET的信念。该定性研究由计划行为理论（TPB）指导。在过去两年（n = 43）中，我们对接受过AET治疗的女性进行了焦点小组讨论和个人访谈。主题指南探讨了态度（感知到的优缺点），规范性（认可或不赞成的感知）以及控制信念（障碍和促进因素），以遵守AET。进行了主题分析。大多数妇女对AET持积极态度，无论其服药行为如何。主要的感知优势是防止复发，而最大的不便是副作用。几乎所有人都同意该妇女服药。这些妇女提到了促进服用药物行为和应对副作用的促进因素。对于依恋女性而言，建立例行程序的困难是她们服药的主要障碍。对于不坚持的妇女，这是影响其生活质量的副作用。这些发现可为社区药房依从性干预措施的发展提供参考。

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