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首页> 美国卫生研究院文献>Clinical Cosmetic and Investigational Dermatology >Association between heterozygote Val92Met MC1R gene polymorphisms with incidence of melasma: a study of Javanese women population in Yogyakarta
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Association between heterozygote Val92Met MC1R gene polymorphisms with incidence of melasma: a study of Javanese women population in Yogyakarta

机译：杂合子Val92Met MC1R基因多态性与黄褐斑发生率之间的关联：日惹爪哇妇女群体的研究

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>Introduction: Melasma is an acquired hypermelanosis of the face. The pathogenesis of melasma is multifactorial and may be caused by interactions between genetics and the environment. Research has shown that skin pigmentation is regulated by the Melanocortin-1 Receptor gene (MC1R). In Japanese populations, Val92Met and Arg163Gln genotypes of MC1R gene polymorphisms are associated with freckles and lentigo solaris, because they have skin types II–III, but for Indonesians who are skin type IV, hyperpigmentation disorders are often melasma.>Purpose: This study aimed to identify the association between Val92Met and Arg163Gln genotypes of MC1R gene polymorphisms with the incidence of melasma in a Javanese women population.>Patients and methods: This study used unmatched case-control design, conducted by clinical examination and questionnaire. Data were analyzed with Chi-squared test and Odds Ratio (OR).>Results: This study evaluated 158 Javanese women from 18–60 years old with 79 case and 79 control subjects. The genotype of Val92Met was found more common in melasma subjects than in non-melasma (p=0.005) with (OR2.53; 95% CI:1.21–5.29). By using a bivariate test we showed sun exposure and family history of melasma were risk factors for melasma (OR:1.99; 95% CI:1.04–3.78) and (OR:35.32; 95% CI:10.25–121.70). However, genotype of Arg163Gln was not a risk factor for the incidence of melasma (OR: 0.86; 95% CI:0.39–1.89).>Conclusion: The findings showed Val92Met genotypes, sun exposure and family history were risk factors for melasma incidence. This is the first study on incidence of melasma in an Indonesian population and contributes to ongoing efforts to understand the mechanisms of melasma.
机译：>简介：黄褐斑是后天面部变黑。黄褐斑的发病机制是多因素的，可能是由遗传学和环境之间的相互作用引起的。研究表明，皮肤色素沉着受Melanocortin-1 Receptor基因（MC1R）调控。在日本人群中，MC1R基因多态性的Val92Met和Arg163Gln基因型与雀斑和斑节菌有关，因为它们的皮肤类型为II-III，但对于皮肤类型为IV的印度尼西亚人来说，色素沉着异常通常是黄褐斑。>目的：< / strong>本研究旨在确定Val92Met和MC1R基因多态性的Arg163Gln基因型与爪哇女性人群黄褐斑的发生率之间的关联。>患者和方法：该研究采用了无与伦比的病例对照设计，通过临床检查和问卷调查进行。通过卡方检验和几率（OR）来分析数据。>结果：该研究评估了158名18至60岁的爪哇妇女，其中有79例病例和79例对照受试者。发现在患有黄褐斑的受试者中，Val92Met的基因型比在具有（OR2.53; 95％CI：1.21-5.29）的非黄褐斑患者中更为常见（p = 0.005）。通过双变量检验，我们发现日光照射和黄褐斑家族史是黄褐斑的危险因素（OR：1.99； 95％CI：1.04-3.78）和（OR：35.32； 95％CI：10.25–121.70）。但是，Arg163Gln的基因型不是黄褐斑发生的危险因素（OR：0.86； 95％CI：0.39–1.89）。>结论：研究结果表明，Val92Met基因型，日光照射和家族史是黄褐斑发病的危险因素。这是关于印尼人群黄褐斑发生率的第一项研究，有助于人们不断努力了解黄褐斑的机制。

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