• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Central-European Journal of Immunology >Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.
【2h】

Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.

机译：白屈菜提取物的抗炎和镇痛作用评价

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the study was to evaluate analgesic activity (“hot plate” test), anti-inflammatory activity (carrageenan-induced paw edema) and locomotor activity in rats under the influence of three fractions of Chelidonium majus herb extract: full water extract (FWE), protein enriched fraction (PEF), and non-protein fraction (NPF). Effects of the fractions on the level of chosen cytokines and their mRNA levels were also assessed using lipopolysaccharide (LPS) administration as a proinflammatory cue. All fractions and diclofenac did not affect the locomotor activity of rats in comparison with the control group. FWE and PEF three hours after administration showed statistically significant analgesic activities comparable to morphine (p < 0.05). A slight reduction in rat paw edema was observed after three (comparable with diclofenac) and six hours in the NPF group. FWE revealed a statistically significant pro-inflammatory effect after three hours in comparison with the control group. Peripheral IL-1 and IL-4 cytokine concentrations were reduced under FWE and NPF, PEF fractions. The combination of FWE, PEF and NPF together with LPS showed only the effects of LPS. We suggest that protein enriched fraction (PEF) produced centrally mediated (morphine-like) analgesic action, whereas the anti-inflammatory potential was shown only after LPS-induced inflammation. The precise mechanisms involved in the production of anti-nociceptive and anti-inflammatory responses of studied fractions are not completely understood, but they may be caused rather by the presence of protein more than alkaloids-enriched fraction. This fraction of the extract could be used as an alternative therapy for the prevention of inflammatory-related diseases in the future, but further studies are needed.
机译：该研究的目的是评估在三倍体白屈菜提取物的影响下，大鼠的镇痛活性（“热板”试验），抗炎活性（角叉菜胶诱发的爪水肿）和运动能力：全水提取物（ FWE），蛋白质富集级分（PEF）和非蛋白质级分（NPF）。还使用脂多糖（LPS）作为促炎线索，评估了这些馏分对所选细胞因子水平及其mRNA水平的影响。与对照组相比，所有级分和双氯芬酸均不影响大鼠的运动能力。给药后三小时的FWE和PEF在统计学上显示了与吗啡相当的镇痛活性（p <0.05）。在NPF组中，三（与双氯芬酸相比）和六小时后，大鼠爪水肿略有减少。与对照组相比，FWE在三小时后显示出统计学上显着的促炎作用。在FWE和NPF，PEF分数下，外周血IL-1和IL-4细胞因子浓度降低。 FWE，PEF和NPF与LPS的组合仅显示LPS的作用。我们建议蛋白质富集部分（PEF）产生中枢介导的（吗啡样）镇痛作用，而仅在LPS诱导的炎症后才显示出抗炎潜力。尚不完全了解所研究馏分的抗伤害感受和抗炎反应的产生的确切机制，但它们可能是由于蛋白质的存在而不是富含生物碱的馏分引起的。提取物的这一部分可在将来用作预防炎症相关疾病的替代疗法，但需要进一步的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号