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Developing a Rapid Algorithm to Enable Rapid Characterization of Alginate Microcapsules

机译：开发快速算法以实现藻酸盐微胶囊的快速表征

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The islets of Langerhans are endocrine tissue clusters that secrete hormones that regulate the body's glucose, carbohydrate, and fat metabolism, the most important of which is insulin, a hormone secreted by β-cells within the islets. In certain instances, a person's own immune system attacks and destroys them, leading to the development of type 1 diabetes (T1D), a life-long condition that needs daily insulin administration to maintain health and prolong survival. Islet transplantation is a surgical procedure that has demonstrated the ability to normalize blood sugar levels for up to a few years, but the need for chronic immunosuppression relegates it to a last resort that is often only used sparingly and in seriously ill patients. Islet microencapsulation is a biomedical innovation designed to protect islets from the immune system by coating them with a biocompatible polymer, and this new technology has demonstrated various degrees of success in small- and large-animal studies. This success is significantly impacted by microcapsule morphology and encapsulation efficiency. Since hundreds of thousands of microcapsules are generated during the process, characterization of encapsulated islets without the help of some degree of automation would be difficult, time-consuming, and error prone due to inherent observer bias. We have developed an image analysis algorithm that can analyze hundreds of microencapsulated islets and characterize their size, shape, circularity, and distortion with minimal observer bias. This algorithm can be easily adapted to similar nano- or microencapsulation technologies to implement stricter quality control and improve biomaterial device design and success.
机译：朗格汉斯的胰岛是内分泌组织簇，分泌的激素可调节人体的葡萄糖，碳水化合物和脂肪代谢，其中最重要的是胰岛素，这是胰岛内β细胞分泌的激素。在某些情况下，一个人自身的免疫系统会攻击并破坏它们，导致1型糖尿病（T1D）的发展，这是一种终生疾病，需要每天注射胰岛素以维持健康并延长生存期。胰岛移植是一种外科手术，已证明能够使血糖水平正常化长达数年之久，但由于需要进行慢性免疫抑制，因此只能将其用于最后一种手段，这种手段通常仅在少数情况下用于重病患者。胰岛微囊化技术是一种生物医学创新技术，旨在通过用生物相容性聚合物包被胰岛来保护胰岛免受免疫系统的侵害，这项新技术已在小型和大型动物研究中证明了不同程度的成功。微胶囊的形态和封装效率极大地影响了这一成功。由于在此过程中产生了成千上万的微胶囊，因此，如果不借助某种程度的自动化，对包囊的胰岛进行表征将很困难，耗时且由于固有的观察者偏见而容易出错。我们开发了一种图像分析算法，可以分析数百个微囊化的胰岛，并以最小的观察者偏倚来表征它们的大小，形状，圆形度和变形。该算法可以轻松地适应类似的纳米或微囊技术，以实现更严格的质量控制并提高生物材料设备的设计和成功率。

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