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首页> 美国卫生研究院文献>Journal of Thyroid Research >Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism
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Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism

机译：左甲状腺素可以服用吗？左甲状腺素早晨和晚上剂量治疗甲状腺功能减退的比较评价

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摘要

152 drug naïve primary hypothyroid patients were divided into morning (Group 1) and evening (Group 2) dosing group and evaluated for change in biochemical profile, physical functioning and Quality of Life during the course of 12 weeks of study. At the end of 12 weeks 70 (90.90%) subjects in Group 1 and 72 (96%) in Group 2 achieved euthyroidism. On evaluation clinical symptoms and total clinical scores improved in both the groups at the end of 6 and 12 weeks. Significant improvement in thyroid profile was seen in both the groups at the end of 6 and 12 weeks (P value <.0001). On intergroup comparison, no significant difference in thyroid profile was seen at 6 and 12 weeks between the morning and the evening dose group. Similar dose of levothyroxine was required to achieve euthyroidism in both the groups. Though an early restoration of euthyroidism was seen in evening group, the difference when compared to the morning group was not statistically significant. On assessment of QoL, statistically significant improvement in various parameters was seen in both the groups. Hence, from the study we inferred that evening dose is as efficacious as morning dose and provides an alternate dosing regimen.
机译：152名初次使用甲状腺功能减退症的原发性甲状腺功能减退患者被分为上午（第1组）和晚上（第2组）给药组，并在研究12周的过程中评估了其生化特征，身体机能和生活质量的变化。在第12周结束时，第1组的70位受试者（90.90％）和第2组的72位受试者（96％）实现了甲状腺功能正常。经过评估，在6周和12周结束时，两组的临床症状和总临床评分均得到改善。在第6周和第12周结束时，两组的甲状腺状况均显着改善（P值<.0001）。在组间比较中，早晨和晚上剂量组之间在第6和12周时，甲状腺特征无明显差异。两组均需要相似剂量的左甲状腺素以实现甲状腺功能正常。尽管在夜间组中发现甲状腺功能正常，但与早晨组相比差异无统计学意义。在QoL评估中，两组的各项参数均在统计学上有显着改善。因此，从研究中我们推断夜间剂量与早晨剂量一样有效，并提供了替代的给药方案。

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