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A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis

机译：Cdc25A中具有人类癌症易感性的多态性在小鼠中具有胚胎致死性并促进ASK-1介导的细胞凋亡

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BackgroundFailure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. During G1 and S and in cellular response to DNA damage, Cdc25A is targeted for degradation through the Skp1-cullin-β-TrCP (SCF^β-TrCP) complex. This complex binds to the Cdc25A DSG motif which contains serine residues at positions 82 and 88. Phosphorylation of one or both residues is necessary for the binding and degradation to occur.

机译：背景技术在细胞周期或检查点应答过程中未能调节Cdc25A磷酸酶水平会导致DNA损伤和复制检查点旁路，从而导致基因组不稳定和癌症。在G1和S期间以及细胞对DNA损伤的反应中，Cdc25A被靶向通过Skp1-cullin-β-TrCP（SCF ^{β-TrCP）复合物降解。该复合物与Cdc25A DSG基序结合，后者在位置82和88处含有丝氨酸残基。一个或两个残基的磷酸化是发生结合和降解所必需的。}

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期刊名称 Cell Division
作者
El Mustapha Bahassi; Moying Yin; Susan B Robbins; Ya-Qin Li; Deborah G Conrady; Zhenyu Yuan; Rhett A Kovall; Andrew B Herr; Peter J Stambrook;
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作者单位

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年(卷),期 2011(6),-1
年度 2011
页码 4
总页数 9
原文格式 PDF
正文语种
中图分类细胞生物学;
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专利

1. A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis [J] . El Mustapha Bahassi, Moying Yin, Susan B Robbins, Cell Division . 2011,第1期

机译：Cdc25A中易于致癌的人类多态性在小鼠中具有胚胎致死性，并促进ASK-1介导的细胞凋亡
2. Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD. [J] . Steve Leu, Yen-Ming Lin, Chu-Han Wu, Journal of Cell Science . 2012,第13期

机译：通过SRSF1介导的Bcl-xS和ICAD的替代表达，Pnn表达的丧失导致小鼠早期胚胎致死率和细胞凋亡。
3. NPAS2 NPAS2 regulates proliferation of acute myeloid leukemia cells via CDC25A CDC25A ‐mediated cell cycle progression and apoptosis [J] . Song Bin, Chen Yan, Liu Yuhong, Journal of cellular biochemistry. . 2019,第5期

机译：NPAS2 NPAS2通过CDC25A CDC25A介导的细胞周期进展和细胞凋亡来调节急性髓性白血病细胞的增殖
4. Early Embryonic Lethality Caused by Targeted Disruption of the Mouse PHGPx Gene [C] . H. Imai, F. Hirao, T. Sakamoto, International Society for Free Radical Research . 2006

机译：通过针对小鼠PHGPX基因的靶向破坏引起的早期胚胎致死性
5. Murine embryonic stem cell fusion-mediated reprogramming of primary mouse embryonic fibroblasts [D] . Ambrosi, Dominic J. 2008

机译：小鼠胚胎干细胞融合介导的小鼠原代胚胎成纤维细胞重编程
6. SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex [O] . Esha Madan, Rajan Gogna, Periannan Kuppusamy, 2013

机译：SCO2通过Thr845的ASK-1磷酸化和ASK-1–Trx复合体的解离诱导p53介导的细胞凋亡。
7. A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis [O] . Kovall Rhett A, Yuan Zhenyu, Conrady Deborah G, 2011

机译：Cdc25A中具有人类癌症易感性的多态性在小鼠中具有胚胎致死性，并促进ASK-1介导的细胞凋亡

A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis

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