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Expression profiling of chromatin-modifying enzymes and global DNA methylation in CD4+ T cells from patients with chronic HIV infection at different HIV control and progression states

机译：处于不同HIV控制和进展状态的慢性HIV感染患者的CD4 + T细胞中染色质修饰酶的表达谱和整体DNA甲基化

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BackgroundIntegration of human immunodeficiency virus type 1 (HIV-1) into the host genome causes global disruption of the chromatin environment. The abundance level of various chromatin-modifying enzymes produces these alterations and affects both the provirus and cellular gene expression. Here, we investigated potential changes in enzyme expression and global DNA methylation in chronically infected individuals with HIV-1 and compared these changes with non-HIV infected individuals. We also evaluated the effect of viral replication and degree of disease progression over these changes.

机译：背景技术人类免疫缺陷病毒1型（HIV-1）整合到宿主基因组中会导致染色质环境的整体破坏。各种染色质修饰酶的丰度水平会产生这些变化，并影响原病毒和细胞基因表达。在这里，我们调查了慢性感染HIV-1的个体中酶表达和总体DNA甲基化的潜在变化，并将这些变化与未感染HIV的个体进行了比较。我们还评估了这些变化对病毒复制和疾病进展程度的影响。

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期刊名称 Clinical Epigenetics
作者
Roberta Nicoleta Bogoi; Alicia de Pablo; Eulalia Valencia; Luz Martín-Carbonero; Victoria Moreno; Helem Haydee Vilchez-Rueda; Victor Asensi; Rosa Rodriguez; Victor Toledano; Berta Rodés;
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年(卷),期 2018(10),-1
年度 2018
页码 20
总页数 10
原文格式 PDF
正文语种
中图分类遗传学;
关键词
HIV Progression Epigenetics Methyltransferases HDAC Chromatin-modifying enzymes DNA methylation;

机译：HIV;疾病进展;表观遗传学;甲基转移酶;HDAC;染色质修饰酶;DNA甲基化;

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1. Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection [J] . Wayne B Dyer, John J Zaunders, Fang Fang Yuan, Retrovirology . 2008,第S1期

机译：艾滋病毒不扩散的机制;对p24抗原的强大而持续的CD4 + T细胞增殖反应与长期输血获得性HIV-1感染后控制病毒血症和疾病进展缺乏相关
2. Discontinuation of primary and secondary prophylaxis for opportunistic infections in HIV-Infected Patients Who Had CD4+ Cell Count 200 cells/mm3 but Undetectable Plasma HIV-1 RNA: An Open-Label Randomized Controlled Trial [J] . ChaiwarithR., PraparattanapanJ., NuntachitN., AIDS patient care and STDs . 2013,第2期

机译：中止CD4 +细胞计数小于200细胞/ mm3但血浆HIV-1 RNA检测不到的HIV感染患者中机会性感染的一级和二级预防：一项开放标签的随机对照试验
3. Highly active antiretroviral therapy restores CD4+ Vbeta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV+ patients with severe chronic infection. [J] . Cossarizza A, Poccia F, Agrati C, JAIDS: Journal of acquired immune deficiency syndromes . 2004,第3期

机译：高活性抗逆转录病毒疗法可恢复原发性急性HIV感染患者的CD4 + Vbeta T细胞库，但对于未接受过治疗的HIV +严重慢性感染的患者则无法恢复。
4. Cluster analysis in assessing the interdependencies of clinical and morphological parameters of patients with mixed infections (pulmonary tuberculosis, chronic viral hepatitis, HIV infection) and heroin addiction [C] . Pigul Evgeniia Yu, Filimonova Galina F., Tokin Ivan B., 2015 International Conference "Stability and Control Processes" in Memory of V.I. Zubov . 2015

机译：聚类分析评估混合感染（肺结核，慢性病毒性肝炎，HIV感染）和海洛因成瘾患者临床和形态学参数之间的相互依赖性
5. Modulation of the CD161+ Double-Negative T cell Population During Progression of HIV-1 Infection to AIDS is Correlated with an Increased Pro-Inflammatory T cell Gene Expression. [D] . Singleterry, Will Landry. 2011

机译：在HIV-1感染艾滋病的过程中CD161 +双重阴性T细胞种群的调节与促炎性T细胞基因表达的增加有关。
6. Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection [O] . Wayne B Dyer, John J Zaunders, Fang Fang Yuan, 2008

机译：艾滋病毒不扩散的机制；对p24抗原的强劲且持续的CD4 + T细胞增殖反应与长期输血获得性HIV-1感染后病毒血症的控制和疾病进展的缺乏相关
7. Expression profiling of chromatin-modifying enzymes and global DNA methylation in CD4+ T cells from patients with chronic HIV infection at different HIV control and progression states [O] . Roberta Nicoleta Bogoi, Alicia de Pablo, Eulalia Valencia, 2018

机译：不同艾滋病毒控制和进展状态下慢性艾滋病毒感染患者CD4 + T细胞中染色质修饰酶的表达分析和全局DNA甲基化

Expression profiling of chromatin-modifying enzymes and global DNA methylation in CD4+ T cells from patients with chronic HIV infection at different HIV control and progression states

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