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Diagnostic and Treatment Approaches for Refractory Peptic Ulcers

机译:难治性消化性溃疡的诊断和治疗方法

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摘要

Refractory peptic ulcers are defined as ulcers that do not heal completely after 8 to 12 weeks of standard anti-secretory drug treatment. The most common causes of refractory ulcers are persistent Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Simultaneous use of two or more H. pylori diagnostic methods are recommended for increased sensitivity. Serologic tests may be useful for patients currently taking proton pump inhibitors (PPIs) or for suspected false negative results, as they are not affected by PPI use. NSAID use should be discontinued when possible. Platelet cyclooxygenase activity tests can confirm surreptitious use of NSAIDs or aspirin. Cigarette smoking can delay ulcer healing. Therefore, patients who smoke should be encouraged to quit. Zollinger-Ellison syndrome (ZES) is a rare but important cause of refractory gastroduodenal ulcers. Fasting plasma gastrin levels should be checked if ZES is suspected. If an ulcer is refractory despite a full course of standard PPI treatment, the dose should be doubled and administration of another type of PPI considered.
机译:难治性消化性溃疡的定义为在标准抗分泌药物治疗8到12周后不能完全治愈的溃疡。顽固性溃疡的最常见原因是持续的幽门螺杆菌感染和使用非甾体抗炎药(NSAIDs)。建议同时使用两种或多种幽门螺杆菌诊断方法以提高敏感性。血清学检查可能对目前正在服用质子泵抑制剂(PPI)的患者或疑似假阴性结果有用,因为它们不受PPI使用的影响。如果可能,应停止使用NSAID。血小板环氧合酶活性测试可以确认秘密使用了NSAID或阿司匹林。吸烟可以延缓溃疡的愈合。因此,应鼓励吸烟的患者戒烟。 Zollinger-Ellison综合征(ZES)是难治性胃十二指肠溃疡的罕见但重要原因。如果怀疑ZES,应检查空腹血浆胃泌素水平。如果在标准PPI治疗的整个过程中溃疡均是顽固性的,则应加倍剂量,并考虑使用另一种PPI。

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