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Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus: Anal Intraepithelial Neoplasia from a Pathologists Point of View

机译:肛门上皮内瘤变和肛门鳞状细胞癌:从病理学家的角度来看肛门上皮内瘤变

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摘要

Anal squamous cell carcinoma is a relatively rare diagnosis, but its incidence has continued to rise. Anal squamous cell carcinoma and its precursor lesion, anal intraepithelial neoplasia (AIN), are human papillomavirus (HPV)-associated squamous neoplasias. High-risk HPV subtypes cause cellular proliferation in the anal transformation zone mucosa leading to similar dysplastic changes as seen in the cervix. Unified cytologic and histologic classification systems have emerged for all HPV-associated squamous lesions of the lower anogenital tract due to recent advancements in the understanding of these lesions. P16 immunohistochemical stain, a biomarker for HPV, is recommended in the diagnosis of HPV-associated lesions. The unity of terminology will aid in communication between pathologists and clinicians, ultimately leading to improved patient care.
机译:肛门鳞状细胞癌是一种相对罕见的诊断,但其发病率持续上升。肛门鳞状细胞癌及其前体病变是肛门上皮内瘤变(AIN),是与人乳头瘤病毒(HPV)相关的鳞状瘤。高危型HPV亚型导致肛门转化区粘膜细胞增殖,导致子宫颈发生类似的发育异常变化。由于最近对这些病变的认识的不断发展,已经出现了统一的细胞学和组织学分类系统,用于所有与生殖器下部相关的HPV相关鳞状病变。建议将P16免疫组化染色剂作为HPV的生物标志物,以诊断HPV相关病变。统一的术语将有助于病理学家和临床医生之间的交流,最终改善患者的护理。

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