• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The Canadian Journal of Infectious Diseases Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie M dicale >Left out but not forgotten: Should closer attention be paid to coinfection with herpes simplex virus type 1 and HIV?
【2h】

Left out but not forgotten: Should closer attention be paid to coinfection with herpes simplex virus type 1 and HIV?

机译：被遗忘但未被遗忘：是否应该更密切关注1型单纯疱疹病毒和HIV的合并感染？

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are among the most common coinfections seen in individuals infected with HIV-1. Most research on HSV-HIV coinfection has focused on HSV-2, and in particular, on its impact on HIV transmission. HSV-2 is associated with micro- and macroulcerations in genital mucosal surfaces, increased numbers of HIV target cells in genital mucosal tissue and increases in plasma HIV viral load of up to 0.5 log10 copies/mL, such that HSV-2 infection increases the risk of both HIV acquisition and transmission. Because plasma HIV RNA levels are a major determinant of rates of CD4 cell decline, HSV-2 coinfection may also adversely affect the progression of HIV disease. Anti-HSV medications have in fact been associated with reciprocal decreases in HIV viral load in short-term studies. These findings have led to the development of several clinical trials of HSV-2 suppression as strategies for preventing HIV transmission and slowing the rate of HIV disease progression. HSV-1 coinfection has largely been ignored from this growing body of research, yet there are several reasons that this coinfection remains an important issue for study. First, the seroprevalence of HSV-1 is consistently higher than that of HSV-2 among both HIV-infected and HIV-uninfected populations, underscoring the relevance of HSV-1 coinfection to the majority of HIV-infected persons. Second, pre-existing HSV-1 antibodies in individuals may modulate the course of subsequently acquired HSV-2 infection; the implications of such changes on HSV-HIV coinfection remain unexplored. Third, HSV-1 and HSV-2 are closely related viruses that share 83% genetic homology. Their virological and pathobiological similarities suggest that their implications on HIV pathogenesis may be similar as well. Finally, HSV-1 is becoming increasingly relevant because the incidence of genital HSV-1 has risen. Although genital herpes is traditionally associated with HSV-2, recent studies have shown that the majority of serologically confirmed primary genital herpes in some settings is attributable to HSV-1. Because the genital tract is an important site of biological interaction between HSV and HIV, this epidemiological change may be clinically important.
机译：单纯疱疹病毒1型（HSV-1）和2型（HSV-2）是感染HIV-1的个体中最常见的合并感染。关于HSV-HIV合并感染的大多数研究都集中在HSV-2，特别是其对HIV传播的影响上。 HSV-2与生殖器粘膜表面的微溃疡和大溃疡，生殖器粘膜组织中HIV靶细胞的数量增加以及血浆HIV病毒载量增加高达0.5 log10拷贝/ mL有关，因此HSV-2感染增加了风险艾滋病毒的获取和传播。因为血浆HIV RNA水平是CD4细胞下降率的主要决定因素，所以HSV-2合并感染也可能对HIV疾病的发展产生不利影响。实际上，在短期研究中，抗HSV药物与HIV病毒载量的倒数下降有关。这些发现促成了多项HSV-2抑制临床试验的发展，作为防止HIV传播和减慢HIV疾病发展速度的策略。 HSV-1合并感染在不断发展的研究中已被很大程度上忽略，但是有多种原因使该合并感染仍然是研究的重要问题。首先，在感染了艾滋病毒的人群和未感染艾滋病毒的人群中，HSV-1的血清阳性率始终高于HSV-2的血清阳性率，强调了HSV-1合并感染与大多数HIV感染者的相关性。其次，个体中预先存在的HSV-1抗体可能会调节随后获得的HSV-2感染的过程。此类变化对HSV-HIV合并感染的影响尚待探索。第三，HSV-1和HSV-2是紧密相关的病毒，具有83％的遗传同源性。它们的病毒学和病理生物学相似性表明，它们对HIV发病机理的影响也可能相似。最后，由于生殖器HSV-1的发病率上升，HSV-1变得越来越重要。尽管生殖器疱疹传统上与HSV-2相关，但最近的研究表明，在某些情况下，经血清学确认的原发性生殖器疱疹多数归因于HSV-1。由于生殖道是HSV与HIV之间生物相互作用的重要部位，因此这种流行病学变化可能在临床上很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号