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首页> 美国卫生研究院文献>The Journal of Physiology >Comparison of the reflex vasomotor responses to separate and combined stimulation of the carotid sinus and aortic arch baroreceptors by pulsatile and non-pulsatile pressures in the dog
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Comparison of the reflex vasomotor responses to separate and combined stimulation of the carotid sinus and aortic arch baroreceptors by pulsatile and non-pulsatile pressures in the dog

机译：比较犬脉动和非脉动压力对单独和联合刺激颈动脉窦和主动脉弓压力感受器的反射性血管舒缩反应的比较

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1. In the anaesthetized dog the carotid sinuses and aortic arch were isolated from the circulation and separately perfused with blood by a method which enabled the mean pressure, pulse pressure and pulse frequency to be varied independently in each vasosensory area. The systemic circulation was perfused at constant blood flow by means of a pump and the systemic venous blood was oxygenated by an extracorporeal isolated pump-perfused donor lung preparation.2. When the vasosensory areas were perfused at non-pulsatile pressures within the normal physiological range of mean pressures, the reflex reduction in systemic vascular resistance produced by a given rise in mean carotid sinus pressure was significantly greater than that resulting from the same rise of aortic arch pressure.3. On the other hand, when the vasosensory areas were perfused at normal pulsatile pressures and within the normal physiological range of mean pressures, there was no difference in the size of the reflex vascular responses elicited by the same rise in mean pressure in the carotid sinuses and in the aortic arch.4. Whereas the vasomotor responses elicited reflexly by changes in mean carotid sinus pressure are modified by alterations in pulse pressure, those evoked by the aortic arch baroreceptors through changes of mean pressure are only weakly affected by modifications in pulse pressure. Evidence for this was obtained from single stepwise changes of mean pressure in each vasosensory area during pulsatile and non-pulsatile perfusion, and from curves relating the mean pressure in the carotid sinuses or aortic arch and systemic arterial perfusion pressure.5. The vasomotor response elicited by combined stimulation of the carotid sinus and aortic arch baroreceptors was greater than either response resulting from their separate stimulation.6. When the mean perfusion pressures in the two vasosensory areas are changed together, the curve relating mean pressure to systemic arterial pressure during pulsatile perfusion of the areas is considerably flatter than that for non-pulsatile perfusion.7. Increasing the pulse pressure in the carotid sinuses or aortic arch caused a decrease in systemic vascular resistance, the response elicited from the carotid sinuses being the larger.8. Altering the phase angle between the pulse pressure waves in the carotid sinuses and aortic arch had no effect on systemic vascular resistance.9. In both vasosensory areas, increasing the pulse frequency caused a reduction in systemic vascular resistance.
机译：1.在麻醉的狗中，将颈动脉窦和主动脉弓从循环中分离出来，并通过一种方法使血液分别灌注，该方法可使每个血管感觉区域的平均压力，脉压和脉搏频率独立变化。用泵以恒定的血流灌注全身循环，并通过体外分离的泵灌注供体肺制备物为全身静脉血充氧。2。当在平均压力的正常生理范围内在非脉动压力下灌注血管感觉区域时，由给定的平均颈动脉窦压力升高引起的全身血管阻力的反射降低显着大于相同主动脉弓升高所引起的反射降低。压力3。另一方面，当在正常搏动压力下以及在正常平均压力的生理范围内灌注血管感觉区域时，由于颈窦和鼻窦的平均压力相同上升而引起的反射性血管反应的大小没有差异。在主动脉弓4。由平均颈动脉窦压力变化反射引起的血管舒缩反应通过脉冲压力的改变而改变，而由主动脉弓压力感受器通过平均压力的变化引起的那些仅受到脉冲压力改变的微弱影响。从脉动性和非脉动性灌注过程中每个血管感觉区域的平均压力的单次逐步变化，以及与颈动脉或主动脉弓的平均压力和全身动脉灌注压力相关的曲线获得的证据。5。联合刺激颈动脉窦和主动脉弓压力感受器引起的血管舒缩反应大于单独刺激引起的任一反应。6。当两个血管感觉区域的平均灌注压力一起改变时，该区域的脉动灌注过程中将平均压力与全身动脉压相关的曲线比非脉动灌注的曲线显着平坦。7。颈动脉窦或主动脉弓的脉压增加导致全身血管阻力降低，颈动脉窦引起的反应更大。8。改变颈动脉窦压力脉搏波与主动脉弓之间的相位角对全身血管阻力没有影响。9。在两个血管感觉区域中，增加脉冲频率会导致全身血管阻力降低。

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