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首页> 美国卫生研究院文献>The Journal of Physiology >The paramedian reticular nucleus: a site of inhibitory interaction between projections from fastigial nucleus and carotid sinus nerve acting on blood pressure
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The paramedian reticular nucleus: a site of inhibitory interaction between projections from fastigial nucleus and carotid sinus nerve acting on blood pressure

机译：网状旁正中核：小脑顶核投射物与颈动脉窦神经之间的抑制性相互作用位点作用于血压

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1. The interaction between the pressor response to electrical stimulation of the fastigial nucleus (FN), the fastigial pressor response (FPR), and the depressor response to electrical stimulation of the carotid sinus nerve (CSN) was examined in paralysed anaesthetized cats.2. Blood pressure responses evoked by electrical stimulation of the FN and the CSN were mutually inhibitory and summed algebraically.3. The FPR was augmented after denervation of buffer nerves. Lesions of the FN did not alter the depressor response to stimulation of the CSN.4. Bilateral electrolytic lesions of the paramedian reticular nucleus abolished both the FPR and the CSN depressor response without altering base line pressure.5. With micro-electrode recording neurones were discovered within the paramedian reticular nucleus which responded to electrical stimulation of the FN or the CSN. These neurones were polysynaptically excited by stimulation of either the FN or the CSN but rarely from both, and could be further subdivided into cells responding with either a single spike or a burst discharge.6. The interaction between the FN and the CSN projections to the paramedian reticular nucleus was examined by conditioning-test studies. Eleven per cent of FN- and CSN-units were inhibited by conditioning stimulation of the heteronymous input. The interaction was exclusively inhibitory and observed only in units with latencies > 4 msec and having burst responses. The latency for inhibition was > 20 msec, peaked around 100 msec and lasted up to 300 msec.7. We conclude that the FRP is buffered by baroreceptors and that there is a mutually inhibitory interaction between projections from the FN and the CSN acting on sympathetic vasomotor neurones. The paramedian reticular nucleus appears to be an important site for the interaction.8. The findings support the view that interneurones mediating pressor and depressor responses are intermixed within the medial reticular formation of the medulla.
机译：1.在瘫痪的麻醉猫中检查了对小脑顶核电刺激（FN）的加压反应，对小颈动脉窦神经（CSN）的加压反应与加压反应之间的相互作用。2 。电刺激FN和CSN引起的血压反应是相互抑制的，并以代数方式相加。3。缓冲神经去神经后，FPR升高。 FN的病变并没有改变对CSN刺激的降压反应。4。在不改变基线压力的情况下，视网膜旁正中网状核的双侧电解损伤消除了FPR和CSN降压反应。5。利用微电极记录，在正中网状核内发现了神经元，该神经元对FN或CSN的电刺激作出反应。这些神经元通过FN或CSN的刺激而被多突触地激发，但很少同时受到两者的刺激，并且可以进一步细分为具有单个尖峰或爆发放电反应的细胞。6。通过条件测试研究检查了FN和CSN投射到网状旁中核之间的相互作用。条件异源输入的刺激会抑制11％的FN和CSN单位。相互作用完全是抑制性的，仅在潜伏期> 4毫秒且具有猝发响应的单位中观察到。抑制潜伏期> 20毫秒，在100毫秒左右达到峰值，持续到300毫秒。7。我们得出结论，FRP由压力感受器缓冲，并且从FN和CSN投射到交感性血管舒缩神经元上的投射之间存在相互抑制的相互作用。网状旁中核似乎是相互作用的重要部位。8。这些发现支持这样一种观点，即介导中间神经元介导升压和降压反应的是混合在延髓内侧网状结构内的。

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