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首页> 美国卫生研究院文献>Bulletin of the World Health Organization >Investigations on the mechanism of DDT resistance in certain anopheline mosquitos
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Investigations on the mechanism of DDT resistance in certain anopheline mosquitos

机译：某些按蚊蚊对滴滴涕抗药性的机制研究

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DDT resistance, first observed some thirteen years ago in houseflies, is rapidly spreading in an alarming number of other insects of public health importance, particularly mosquitos. But while much has been learned of the mechanism of this resistance in houseflies, little is known as yet of the corresponding mechanism in mosquitos. A WHO-sponsored study was designed to find out primarily whether, as in houseflies, the breakdown of DDT to DDE—a non-toxic metabolite—in vivo is the predominant factor responsible for the development of resistance in anopheline mosquitos.No definite correlation could be established between the detoxication of DDT and resistance in the anophelines tested, but the interesting fact emerged that the detoxication potential was a measure of the ratio of DDE to absorbed DDT rather than of the ratio of DDT recovered. A multiplicity of factors governs the development of resistance in mosquitos, each species possessing a ”combination of attributes for resistance” that may differ from that of other species; some of these are discussed.
机译：大约13年前在家蝇中首次发现的对DDT的抗药性正在迅速传播，数量惊人的其他具有公共卫生重要性的昆虫，尤其是蚊子。但是，尽管人们已经了解了家蝇中这种抗药性的机制，但对于蚊子中相应抗药性的机制知之甚少。一项由WHO赞助的研究旨在主要研究体内DDT是否分解为DDE（一种无毒代谢产物），这是导致按蚊蚊子产生抗药性的主要因素。没有明确的相关性在DDT的脱毒与被试按蚊之间的抗药性之间建立了联系，但有趣的事实是，脱毒的潜力是DDE与DDT吸收比率的度量，而不是DDT回收率的度量。多种因素决定着蚊子中抗药性的发展，每个物种都具有“抗药性组合”，可能与其他物种不同。其中一些被讨论。

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