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Screening of Tanzanian women of childbearing age for urinary schistosomiasis: validity of urine reagent strip readings and self-reported symptoms.

机译:坦桑尼亚育龄妇女泌尿道血吸虫病筛查:尿液试剂条读数的有效性和自我报告的症状。

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摘要

The screening of women of childbearing age for haematuria, leukocyturia and proteinuria to detect urinary schistosomiasis can be confounded by several factors such as menstruation, pregnancy and genitourinary infections. We therefore undertook a study in an area endemic for Schistosoma haematobium in the United Republic of Tanzania to carry out the following: assess the sensitivity, specificity and predictive values--in women of childbearing age--of indirect indicators of urinary schistosomiasis, as measured by urine reagent strip readings; assess the predictive values of self-reported symptoms; and finally to estimate the morbidity attributable to S. haematobium. A total of 303 women (128 and 175, respectively, living in high- and low-risk sites) participated in the study. Haematuria was more frequent among women excreting S. haematobium eggs than among those who did not (65% versus 32%). The predictive potential of all indirect disease markers was poor in the highly endemic site, while in the sites with low endemicity the negative predictive values were high. Among infected women, 54% of haematuria could be attributed to S. haematobium, but for patients with more than 10 eggs/10 ml the attributable fraction rose to 70%. Symptoms of "bloody urine" and "pain while urinating" were recalled significantly more often by women living in the highly endemic site. On a population level, one-third of the self-reported cases with bloody urine could be attributed to urinary schistosomiasis. Screening of women of childbearing age for urinary schistosomiasis using urine reagent strips can be biased in two directions. The prevalence of S. haematobium will be overestimated if other causes of haematuria, such as reproductive tract infections, are highly endemic. On the other hand, women with light or very light infections will be missed and will not be treated. This is of concern because genital schistosomiasis, a possible risk factor for the transmission of HIV, occurs among women even with light infections.
机译:对育龄妇女进行血尿,白细胞增多症和蛋白尿的筛查以检测尿血吸虫病可能与月经,妊娠和泌尿生殖道感染等多种因素混淆。因此,我们在坦桑尼亚联合共和国的血吸虫血吸虫病地方进行了一项研究,以开展以下工作:评估对育龄妇女的血吸虫病间接指标的敏感性,特异性和预测值通过尿液试剂条读数;评估自我报告症状的预测价值;并最终估算出血红球菌的发病率。共有303名妇女(分别位于高风险和低风险地区的128名妇女和175名妇女)参加了该研究。排尿链球菌卵的妇女中血尿症的发生率比未排卵妇女更高(65%对32%)。在高流行地区,所有间接疾病标记物的预测潜力均较差,而在低流行地区,其负预测值较高。在受感染的妇女中,血尿的54%可能归因于血球链球菌,但对于鸡蛋超过10毫升/ 10毫升的患者,可归因的比例上升至70%。生活在高流行地区的妇女更常回想起“尿尿”和“排尿时疼痛”的症状。在人群水平上,三分之一的自我报告的带血尿的病例可归因于尿血吸虫病。使用尿液试剂条对育龄妇女进行尿血吸虫病的筛查可以偏向两个方向。如果血尿的其他原因(例如生殖道感染)是高度流行的,血友病链球菌的患病率将被高估。另一方面,轻度或极轻度感染的妇女将被漏诊,将不会得到治疗。这令人担忧,因为生殖器血吸虫病是HIV传播的可能危险因素,即使在轻度感染的女性中也会发生。

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