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The diagnosis and management of pre-invasive breast disease: Pathological diagnosis – problems with existing classifications

机译:浸润前乳腺疾病的诊断和管理:病理学诊断-现有分类存在的问题

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摘要

In this review, we comment on the reasons for disagreement in the concepts, diagnosis and classifications of pre-invasive intraductal proliferations. In view of these disagreements, our proposal is to distinguish epithelial hyperplasia, lobular carcinoma in situ and ductal carcinoma in situ, and to abandon the use of poorly reproducible categories, such as atypical ductal hyperplasia or ductal intraepithelial neoplasia, followed by a number to indicate the degree of proliferation and atypia, as these are not practical for clinical decision making, nor for studies aimed at improving the understanding of breast cancer development. If there is doubt about the classification of an intraductal proliferation, a differential diagnosis and the reason for and degree of uncertainty should be given, rather than categorizing a proliferation as atypical.
机译:在这篇综述中,我们评论了在浸润前导管内增生的概念,诊断和分类上存在分歧的原因。鉴于这些分歧,我们的建议是区分上皮增生,原位小叶癌和原位导管癌,并放弃使用可重复性差的类别,例如非典型导管增生或导管上皮内瘤变,并用数字表示增殖和非典型性的程度,因为这些对于临床决策或旨在增进对乳腺癌发展的了解的研究都不实用。如果对导管内增生的分类存在疑问,则应给出鉴别诊断以及不确定性的原因和程度,而不是将增生归为非典型。

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