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首页> 美国卫生研究院文献>Breast Cancer Research : BCR >Ductal-lobar organisation of human breast tissue its relevance in disease and a research objective: vector mapping of parenchyma in complete breasts (the Astley Cooper project)
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Ductal-lobar organisation of human breast tissue its relevance in disease and a research objective: vector mapping of parenchyma in complete breasts (the Astley Cooper project)

机译：人乳腺组织的球状叶组织其在疾病中的相关性和研究目标：完整乳房中实质的矢量绘图（Astley Cooper项目）

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A human breast has many lobes, which are highly variable in size and shape, each with one central duct, its peripheral branches and their associated glandular tissues. Realising the potential of new endoductal approaches to breast diagnosis and improving our understanding of breast cancer precursors will require greatly improved knowledge of this ductal-lobar anatomy and the distribution of cancer precursors within it. This architecture is very challenging to study in its entirety: whole-breast lobe mapping has only been achieved for two human breasts. Clearly, much more efficient techniques are required. Streamlined data capture and visualisation of breast parenchymal anatomy from thin and thick sections in a vector format would allow integrated mapping of whole-breast structure with conventional histology and molecular data. The 'Astley Cooper digital breast mapping project' is proposed as a name for this achievable research objective. Success would offer new insights into the development of breast cancer precursor lesions, allow testing of the important 'sick lobe' hypothesis, improve correlation with imaging studies and provide 'ground truth' for mathematical modelling of breast growth.
机译：人的乳房有许多裂片，其大小和形状高度可变，每个裂片都有一个中央导管，其周边分支及其相关的腺组织。认识到新的导管内方法在乳腺诊断中的潜力并增进我们对乳腺癌前体的了解，将需要大大提高对这种导管大叶解剖结构及其中癌症前体分布的了解。要全面研究这种架构非常困难：仅对两个人的乳房进行了全乳腺映射。显然，需要更有效的技术。以矢量格式对薄壁和厚壁部分的乳房实质解剖结构进行简化的数据捕获和可视化，可以将整个乳房结构与常规组织学和分子数据进行综合映射。提议将“ Astley Cooper数字化乳房映射项目”作为这一可实现的研究目标的名称。成功将为乳腺癌前体病变的发展提供新的见解，允许检验重要的“病灶”假说，改善与影像学研究的相关性，并为乳腺癌生长的数学建模提供“基础事实”。

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