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首页> 美国卫生研究院文献>Brazilian Journal of Microbiology >Antimycobacterial activity of a Brevibacillus laterosporusstrain isolated from a moroccan soil
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Antimycobacterial activity of a Brevibacillus laterosporusstrain isolated from a moroccan soil

机译：从摩洛哥土壤中分离到的一株短芽孢杆菌的抗分枝杆菌活性

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摘要

The treatment of tuberculosis has become more difficult with the worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. Moreover, the prevalence of human disease caused by atypical mycobacteria has also increased in the past two decades and has further complicated the problem of the treatment of mycobacterial infections. It is therefore urgent to develop new highly active molecules against these bacteria. The present study reports the isolation from a Moroccan soil of a Bacillus strain that exhibits an important antimycobacterial activity. The strain was identified as Brevibacillus laterosporus using DNA sequencing of the 16S ribosomal RNA gene. The antimycobacterial activity was assigned to a substance with a protein nature. This nature was revealed using a liquid-liquid extraction with organic solvents, precipitation with ammonium sulfate and treatment with a protease. This study suggested the identification and the characterization of this active metabolite enabling therapeutic investigations further.
机译：随着结核分枝杆菌的多重耐药（MDR）和广泛耐药（XDR）菌株在世界范围内的传播，结核病的治疗变得更加困难。此外，在过去的二十年中，由非典型分枝杆菌引起的人类疾病的患病率也增加了，并使分枝杆菌感染的治疗问题更加复杂。因此，迫切需要开发出针对这些细菌的新型高活性分子。本研究报告从摩洛哥土壤中分离出一种表现出重要抗分枝杆菌活性的芽孢杆菌菌株。使用16S核糖体RNA基因的DNA测序，该菌株被鉴定为晚孢短杆菌。抗分枝杆菌活性被赋予具有蛋白质性质的物质。通过用有机溶剂进行液-液萃取，用硫酸铵沉淀和用蛋白酶处理来揭示这种性质。这项研究表明，这种活性代谢产物的鉴定和表征可以进一步进行治疗研究。

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