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首页> 美国卫生研究院文献>Brazilian Journal of Medical and Biological Research >Sedative and anesthetic activities of the essentialoils of Hyptis mutabilis (Rich.) Briq. and their isolatedcomponents in silver catfish (Rhamdia quelen)
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Sedative and anesthetic activities of the essentialoils of Hyptis mutabilis (Rich.) Briq. and their isolatedcomponents in silver catfish (Rhamdia quelen)

机译：镇静和麻醉活动必不可少Hyptis mutabilis（Rich。）和他们孤立cat鱼中的成分（Rhamdia quelen）

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This study evaluated the sedative and anesthetic effects of the essential oils (EO) of Hyptis mutabilis (Rich.) Briq. and their isolated components on silver catfish (Rhamdia quelen). Quantitative chemical differences between the EOs obtained from leaves and inflorescences were verified, and a new chemotype rich in globulol was described. Although there were no significant differences in the time of induction for sedation and anesthesia between the EOs, only the leaf EO at 344 mg/L anesthetized all fish without side effects. Fractionation of the leaf EO was carried out by column chromatography. The isolated compounds [(+)-1-terpinen-4-ol and (-)-globulol] showed different activity from that detected for the leaf EO in proportional concentrations and similar sedation to a eugenol control at 10 mg/L. However, fish exposed to 1-terpinen-4-ol (3 and 10 mg/L) did not remain sedated for 30 min. Anesthesia was obtained with 83-190 mg/L globulol, but animals showed loss of mucus during induction and mortality at these concentrations. Synergism of the depressor effects was detected with the association of globulol and benzodiazepine (BDZ), compared with either drug alone. Fish exposed to BDZ or globulol+BDZ association showed faster recovery from anesthesia in watercontaining flumazenil, but the same did not occur with globulol. In conclusion,the use of globulol in aquaculture procedures should be considered only atsedative concentrations of 10 and 20 mg/L, and its mechanism of action seems notto involve the GABAA-BDZ system.
机译：该研究评估了Hyptis mutabilis（Rich。）Briq。的精油（EO）的镇静和麻醉作用。及其在银cat鱼上的分离成分（Rhamdia quelen）。验证了从叶和花序获得的EO之间的定量化学差异，并描述了一种富含球蛋白的新化学型。尽管EO之间的镇静和麻醉诱导时间没有显着差异，但只有344 mg / L的叶EO可以麻醉所有鱼类，而没有副作用。叶EO的分馏通过柱色谱法进行。分离的化合物[（+）-1-萜品-4-醇和（-）-球蛋白]的活性与按比例浓度的叶子EO所检测到的活性不同，并且与丁子香酚的10 mg / L镇定相似。但是，暴露于1-萜品四醇（3和10 mg / L）的鱼在30分钟内未保持镇静作用。用83-190 mg / L的球蛋白进行麻醉，但是在这些浓度下，动物在诱导期间粘液流失并导致死亡。与单独使用任何一种药物相比，通过球蛋白和苯二氮卓（BDZ）的联合检测到了抑制作用的协同作用。暴露于BDZ或globulol + BDZ结合的鱼在水中麻醉后恢复更快含有氟马西尼，但球蛋白却没有。结论，仅在以下情况下才应考虑在水产养殖程序中使用球蛋白镇静剂浓度为10和20 mg / L，其作用机制似乎不明显涉及GABAA-BDZ系统。

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