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首页> 美国卫生研究院文献>Brazilian Journal of Medical and Biological Research >A forced running wheel system with a microcontroller that provideshigh-intensity exercise training in an animal ischemic stroke model
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A forced running wheel system with a microcontroller that provideshigh-intensity exercise training in an animal ischemic stroke model

机译：带有微控制器的强制行走系统动物缺血性中风模型中的高强度运动训练

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We developed a forced non-electric-shock running wheel (FNESRW) system that provides rats with high-intensity exercise training using automatic exercise training patterns that are controlled by a microcontroller. The proposed system successfully makes a breakthrough in the traditional motorized running wheel to allow rats to perform high-intensity training and to enable comparisons with the treadmill at the same exercise intensity without any electric shock. A polyvinyl chloride runway with a rough rubber surface was coated on the periphery of the wheel so as to permit automatic acceleration training, and which allowed the rats to run consistently at high speeds (30 m/min for 1 h). An animal ischemic stroke model was used to validate the proposed system. FNESRW, treadmill, control, and sham groups were studied. The FNESRW and treadmill groups underwent 3 weeks of endurance running training. After 3 weeks, the experiments of middle cerebral artery occlusion, the modified neurological severity score (mNSS), an inclined plane test, and triphenyltetrazolium chloride were performed to evaluate the effectiveness of the proposed platform. The proposed platform showed that enhancement of motor function, mNSS, and infarct volumes was significantly stronger in the FNESRW group than the control group (P<0.05) and similar to the treadmill group. The experimental data demonstrated that the proposedplatform can be applied to test the benefit of exercise-preconditioning-inducedneuroprotection using the animal stroke model. Additional advantages of the FNESRWsystem include stand-alone capability, independence of subjective human adjustment,and ease of use.
机译：我们开发了强制非电击跑步轮（FNESRW）系统，该系统使用微控制器控制的自动运动训练模式为大鼠提供高强度运动训练。拟议的系统成功突破了传统的电动跑轮，使老鼠能够进行高强度训练，并且能够在没有任何电击的情况下，以相同的运动强度与跑步机进行比较。在车轮的外围涂有橡胶表面粗糙的聚氯乙烯跑道，以便进行自动加速训练，并允许大鼠在高速下（30 m / min持续行驶1 h）持续行驶。使用动物缺血性中风模型来验证所提出的系统。研究了FNESRW，跑步机，对照组和假组。 FNESRW和跑步机组接受了3周的耐力跑步训练。 3周后，进行了大脑中动脉闭塞，改良的神经系统严重程度评分（mNSS），斜面试验和三苯基四唑氯化物的实验，以评估该平台的有效性。所提出的平台显示，FNESRW组的运动功能，mNSS和梗死体积的增强明显强于对照组（P <0.05），与跑步机组相似。实验数据表明平台可用于测试运动预处理引起的益处使用动物中风模型进行神经保护。 FNESRW的其他优点系统包括独立功能，主观人为调整的独立性，和易用性。

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