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首页> 美国卫生研究院文献>Brazilian Journal of Medical and Biological Research >Long-term efficacy of a rural community-based integrated intervention forprevention and management of chronic obstructive pulmonary disease: a clusterrandomized controlled trial in Chinas rural areas
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Long-term efficacy of a rural community-based integrated intervention forprevention and management of chronic obstructive pulmonary disease: a clusterrandomized controlled trial in Chinas rural areas

机译：农村社区综合干预的长期疗效慢性阻塞性肺疾病的预防和管理：一个集群中国农村地区的随机对照试验

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This study aimed to assess the efficacy of a rural community-based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China. This 18-year cluster-randomized controlled trial encompassing 15 villages included 1008 patients (454 men and 40 women in the intervention group [mean age, 54 ± 10 years]; 482 men and 32 women in the control group [mean age, 53 ± 10 years]) with confirmed COPD or at risk for COPD. Villages were randomly assigned to the intervention or the control group, and study participants residing within the villages received treatment accordingly. Intervention group patients took part in a program that included systematic health education, smoking cessation counseling, and education on management of COPD. Control group patients received usual care. The groups were compared after 18 years regarding the incidence of COPD, decline in lung function, and mortality of COPD. COPD incidence was lower in the intervention group than in the control group (10% vs 16%, <0.05). A decline in lung function was also significantly delayed in the intervention group compared to the control group of COPD and high-risk patients. The intervention group showed significant improvement in smoking cessation compared with the control group, and smokers in the interventiongroup had lower smoking indices than in the control group (350 vs450, <0.05). The intervention group also had a significantly lower cumulativeCOPD-related death rate than the control group (37% vs 47%,<0.05). A rural community-based integrated intervention is effective in reducingthe incidence of COPD among those at risk, delaying a decline in lung function inCOPD patients and those at risk, and reducing mortality of COPD.
机译：本研究旨在评估农村社区综合干预对中国慢性阻塞性肺疾病（COPD）的早期预防和管理的有效性。这项涵盖15个村庄的18年整群随机对照试验包括1008例患者（干预组454名男性和40名女性[平均年龄，54±10岁]；对照组482名男性和32名女性[平均年龄，53± 10年]），并确认患有COPD或有COPD风险。将村庄随机分配到干预组或对照组，居住在村庄内的研究参与者相应地接受治疗。干预组患者参加了一项计划，其中包括系统的健康教育，戒烟咨询和COPD管理教育。对照组患者接受常规护理。 18年后比较各组的COPD发生率，肺功能下降和COPD死亡率。干预组的COPD发生率低于对照组（10％vs 16％，<0.05）。与COPD对照组和高危患者相比，干预组的肺功能下降也明显延迟。干预组与对照组相比，戒烟明显改善，吸烟者干预组的吸烟指数低于对照组（350 vs450，<0.05）。干预组的累积性也明显降低COPD相关死亡率高于对照组（37％比47％，<0.05）。以农村社区为基础的综合干预措施可有效减少高危人群中COPD的发生，延缓了肺功能的下降COPD患者和有风险的患者，可降低COPD的死亡率。

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