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首页> 美国卫生研究院文献>Brazilian Journal of Medical and Biological Research >Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of Cnidoscolus quercifolius Pohl
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Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of Cnidoscolus quercifolius Pohl

机译：槲寄生水提取物的毒性和降血糖作用的评价

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Diabetes mellitus is one of the most common chronic degenerative diseases, and it is estimated to increase worldwide to around 415 million and to impact 642 million in 2040. Research shows that some plants are sources of bioactive compounds against diabetes. Thus, the objective of this work was to evaluate the oral toxicity and the hypoglycemic effect of the aqueous extract of the leaves of Cnidoscolus quercifolius Pohl. Diabetes was induced in Swiss mice with streptozotocin and the mice were treated with an aqueous extract of C. quercifolius leaves for a period of 30 days. Phytochemical analysis showed that the extract was rich in flavonoids, catechins and triterpenoid, which did not show any mortality and behavioral alterations in mice treated with 200, 1000, and 2000 mg/kg body weight of the extract for 14 days. Histopathological analysis of organs (kidney, pancreas, liver) from mice treated with the 2000 mg/kg extract revealed no architectural change. In the present study, we found a 29% reduction in glucose levels in animals receiving 200 mg/kg body weight. These results are very promising because they showed that C. quercifolius had a hypoglycemic effect and did not present oral toxicity, thus being a new source of compounds for the control of diabetes.
机译：糖尿病是最常见的慢性退行性疾病之一，据估计在全世界范围内将增加到约4.15亿，并在2040年影响6.42亿。研究表明，某些植物是抗糖尿病的生物活性化合物的来源。因此，这项工作的目的是评估Cnidoscolus quercifolius Pohl叶片的水提取物的口服毒性和降血糖作用。在瑞士小鼠中用链脲佐菌素诱导糖尿病，并用槲皮衣藻叶的水提取物处理小鼠30天。植物化学分析表明，提取物富含类黄酮，儿茶素和三萜类化合物，在以200、1000和2000 mg / kg体重的提取物处理14天的小鼠中未显示任何死亡率和行为改变。用2000 mg / kg提取物处理的小鼠器官（肾脏，胰腺，肝脏）的组织病理学分析显示，其结构无变化。在本研究中，我们发现接受200 mg / kg体重的动物的葡萄糖水平降低了29％。这些结果是非常有希望的，因为它们表明C. quercifolius具有降血糖作用，并且没有口服毒性，因此是控制糖尿病的新化合物。

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