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首页> 美国卫生研究院文献>British Journal of Clinical Pharmacology >Roles of hepatic blood flow and enzyme activity in the kinetics of propranolol and sotalol.
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Roles of hepatic blood flow and enzyme activity in the kinetics of propranolol and sotalol.

机译：肝血流量和酶活性在心得安和索他洛尔动力学中的作用。

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摘要

1 The roles of the hepatic blood flow and the drug oxidizing enzyme system in eliminating oral propranolol and sotalol were studied in twelve subjects with biopsy proven liver parenchymal disease. 2 The apparent plasma clearance of propranolol was closely related both to the in vivo (antipyrine test) and in vitro (cytochrome P-450) indices of the activity of the hepatic mixed function oxidase system. 3 Propranolol clearance had also a clear relationship to the estimated liver blood flow. Altered flow was, however, suggested to be a minor factor when compared with changes in the enzyme system. 4 The elimination rate of sotalol had no correlation to the indices of hepatic drug metabolism or to the estimated liver blood flow. 5 It is concluded that both the deteriorated sinusoidal perfusion and the decreased mass of drug metabolizing enzymes may be responsible for the impaired elimination of oral propranolol in subjects with parenchymal liver disease.
机译：1在十二个经活检证实为肝实质疾病的受试者中研究了肝血流量和药物氧化酶系统在消除口服普萘洛尔和索他洛尔中的作用。 2普萘洛尔的表观血浆清除率与肝脏混合功能氧化酶系统活性的体内（安替比林试验）和体外（细胞色素P-450）指标密切相关。 3普萘洛尔清除率也与估计的肝血流量有明确的关系。然而，与酶系统的变化相比，改变的流量被认为是次要因素。 4索他洛尔的消除率与肝药物代谢指标或估计的肝血流量无关。 5结论是，肝实质疾病患者正弦曲线灌注恶化和药物代谢酶质量降低均可能与口服普萘洛尔的消除受损有​​关。

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